Activities of Ten Essential Oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 Cancer Cells

Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China.
Molecules (Impact Factor: 2.42). 05/2010; 15(5):3200-10. DOI: 10.3390/molecules15053200
Source: PubMed


Ten essential oils, namely, mint (Mentha spicata L., Lamiaceae), ginger (Zingiber officinale Rosc., Zingiberaceae), lemon (Citrus limon Burm.f., Rutaceae), grapefruit (Citrus paradisi Macf., Rutaceae), jasmine (Jasminum grandiflora L., Oleaceae), lavender (Mill., Lamiaceae), chamomile (Matricaria chamomilla L., Compositae), thyme (Thymus vulgaris L., Lamiaceae), rose (Rosa damascena Mill., Rosaceae) and cinnamon (Cinnamomum zeylanicum N. Lauraceae) were tested for their antibacterial activities towards Propionibacterium acnes and in vitro toxicology against three human cancer cell lines. Thyme, cinnamon and rose essential oils exhibited the best antibacterial activities towards P. acnes, with inhibition diameters of 40 +/- 1.2 mm, 33.5 +/- 1.5 mm and 16.5 +/- 0.7 mm, and minimal inhibitory concentrations of 0.016% (v/v), 0.016% (v/v) and 0.031% (v/v), respectively. Time-kill dynamic procedures showed that thyme, cinnamon, rose, and lavender essential oils exhibited the strongest bactericidal activities at a concentration of 0.25% (v/v), and P. acnes was completely killed after 5 min. The thyme essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% (IC(50)) values on PC-3, A549 and MCF-7 tumor cell lines were 0.010% (v/v), 0.011% (v/v) and 0.030% (v/v), respectively. The cytotoxicity of 10 essential oils on human prostate carcinoma cell (PC-3) was significantly stronger than on human lung carcinoma (A549) and human breast cancer (MCF-7) cell lines.

1 Follower
44 Reads
  • Source
    • "and attracted much attention as complementary and alternative therapy (Zu et al., 2010). Additionally, they offer potential novel template molecules and mixtures of bioactive compounds that can be exploited industrially as bio-products for both the wellness , pharmaceutical and food industry. "
    [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study was to evaluate the antimicrobial properties of essential oils (EOs) isolated from 7 exotic and 2 endemic medicinal plants of Mauritius. Eighteen microorganisms (bacterial and fungal isolates) have been used to evaluate the antimicrobial potential of the EOs as well as their ability to potentiate conventional antibiotics. Significant antibacterial activities were recorded with low minimal inhibitory concentration for 8 of the EOs using the microbroth dilution assay except for Salvia officinalis, where the activity recorded was comparable to that of the antibiotics. The synergistic effect of the EOs of Pimenta dioica, Psiadia arguta and Piper betle were observed against Escherichia coli and Staphylococcus epidermidis when combined with gentamicin. The fungicidal and fungistatic effect of the EOs were observed among all the fungi irrespective of the family except for Trichophyton mentagrophytes. Forty three major compounds were identified using the gas chromatography–mass spectrometry method and predominantly composed of oxygenated monoterpenes at a dose ranging from 0.45% to 69.76%, while, in the case of P. dioica, the EO was predominantly composed of aromatic compounds at a dose of 89.22%. This study has provided key information on the antimicrobial property and phytochemical composition of some tropical medicinal plants from Mauritius.
    Industrial Crops and Products 09/2015; 71. DOI:10.1016/j.indcrop.2015.03.058 · 2.84 Impact Factor
  • Source
    • "Its half inhibitory concentration (IC 50 ) value on PC-3 tumor cell line was 0.010% (v/v) [32]. EO of Mentha arvensis showed cytotoxic activity on LNCaP cells [33]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Essential oils are widely used in pharmaceutical, sanitary, cosmetic, agriculture and food industries for their bactericidal, virucidal, fungicidal, antiparasitical and insecticidal properties. Their anticancer activity is well documented. Over a hundred essential oils from more than twenty plant families have been tested on more than twenty types of cancers in last past ten years. This review is focused on the activity of essential oils and their components on various types of cancers. For some of them the mechanisms involved in their anticancer activities have been carried out.
    American Journal of Cancer Research 11/2014; 4(6):591-607. · 4.17 Impact Factor
  • Source
    • "Our results are consistent with other studies which demonstrated a dose dependent proliferation inhibition of human cancer cell lines from breast cancer, leukemia, cervical epithelial carcinoma, oral cavity squamous cell carcinoma, lung carcinoma and prostate carcinoma [11, 13, 14, 17]. T. vulgaris essential oil were previously shown to interfere with the transcription of genes involved in the cell cycle, cell death and cancer, namely, interferon signaling, N-glycan biosynthesis and extracellular signal-regulated kinase 5 (ERK5) signaling [13]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Background Natural products including, traditional medicinal plants have emerged as a tempting alternative to conventional chemotherapeutic protocols of leukemia because of their minimum side effects and less documented drug resistance. Methods Ethanol extracts were prepared from Thymus vulgaris L. and Origanum syriacum L. plants and investigated against the THP-1 leukemia cell line and freshly isolated peripheral blood mononuclear cells (PBMCs). The 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay and the lactate dehydrogenase (LDH) assay were respectively used to determine the cellular viability and cytotoxicity in response to treatment with increasing extract concentrations. Results Both extracts exhibited a concentration dependent reduction in viability of the THP-1 cells (IC50 = 2.126 mg/mL for O. syriacum, and 0.1569 mg/mL for T. vulgaris). O. syriacum was more potent against the PBMCs (IC50 = 0.4247 mg/mL), while T. vulgaris was moderately selective (IC50 = 0.3345 mg/mL with PBMCs and SI = 2.1). Only in O. syriacum the reduction in cells viability was caused by cytotoxic effect against leukemic cells (LC50 = of 9.646 mg/mL). Conclusion T. vulgaris and O. syriacum are both antileukemic in vitro. T. vulgaris represents a potential selective cytostatic and safe target for future anticancer agents’ development. O. syriacum on the other hand is cytotoxic against the leukemia cell line THP-1.
    BMC Research Notes 09/2014; 7(1):612. DOI:10.1186/1756-0500-7-612
Show more


44 Reads
Available from