Article

Genotype variation of Trypanosoma cruzi isolates from different Brazilian biomes.

Laboratório de Biologia de Tripanosomatídeos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21045-900, Brazil.
Experimental Parasitology (impact factor: 2.12). 01/2011; 127(1):308-12. DOI:10.1016/j.exppara.2010.07.013 pp.308-12
Source: PubMed

ABSTRACT Chagas disease is an enzootic disease, in which the flagellate Trypanosoma cruzi infects a large variety of animals. Humans are accidentally infected due to the migration into wild environments. To identify T. cruzi discrete typing units (DTUs), 19 Brazilian isolates from different biomes and hosts were analyzed by PCR amplification of 24Sα rRNA, 18S rRNA and mini-exon gene sequences. The majority of the isolates was classified as TcIIb (TcII) but subtypes TcIIc (TcIII) and TcIId (TcV) were also identified. In addition, in monkeys TcI was detected.

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Keywords

24Sα rRNA
 
different biomes
 
DTUs
 
flagellate Trypanosoma cruzi infects
 
mini-exon gene sequences
 
monkeys TcI
 
PCR amplification
 
subtypes TcIIc
 
T. cruzi discrete typing units
 
TcII
 
TcIIb
 
TcIId
 
TcIII
 
wild environments