SRD5A3: A surprising role in glycosylation.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.
Cell (Impact Factor: 33.12). 07/2010; 142(2):196-8. DOI: 10.1016/j.cell.2010.07.003
Source: PubMed

ABSTRACT The steroid 5alpha-reductase (SRD5A) family of enzymes produces steroid hormones that regulate male sexual development. Now, Cantagrel et al. (2010) identify a member of this family, SRD5A3, as a polyprenol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as the cause of a rare Mendelian disease.

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