The diagnosis of young-onset dementia. Lancet Neurol 9:793-806

Dementia Research Centre, Department of Neurodegeneration, UCL Institute of Neurology, Queen Square, London, UK.
The Lancet Neurology (Impact Factor: 21.9). 08/2010; 9(8):793-806. DOI: 10.1016/S1474-4422(10)70159-9
Source: PubMed


A diagnosis of dementia is devastating at any age but diagnosis in younger patients presents a particular challenge. The differential diagnosis is broad as late presentation of metabolic disease is common and the burden of inherited dementia is higher in these patients than in patients with late-onset dementia. The presentation of the common degenerative diseases of late life, such as Alzheimer's disease, can be different when presenting in the fifth or sixth decade. Moreover, many of the young-onset dementias are treatable. The identification of causative genes for many of the inherited degenerative dementias has led to an understanding of the molecular pathology, which is also applicable to later-onset sporadic disease. This understanding offers the potential for future treatments to be tailored to a specific diagnosis of both young-onset and late-onset dementia.

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Available from: Cath Mummery, Dec 12, 2014
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    • "Recently there has been a growing interest for highdimensional feature selection and classification methods that can combine information from the whole brain measurement [4] and neuropsychological data [5] to discriminate between individual subjects. Moreover another study indicates that not only older population but also men and women under the age of 50 are affected by dementia [6]. There are several studies that have proved the effective utilization of neuropsychological test data [7] [8] [9] for earlier diagnosis of dementia and for conversion from Mild Cognitive Impairment to Dementia. "
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