Article

Functional magnetic resonance imaging and diffusion tensor tractography incorporated into an intraoperative 3-dimensional ultrasound-based neuronavigation system: impact on therapeutic strategies, extent of resection, and clinical outcome.

Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Department of Medical Imaging, St. Olavs Hospital, Trondheim, Norway.
Neurosurgery (impact factor: 2.79). 08/2010; 67(2):251-64. DOI:10.1227/01.NEU.0000371731.20246.AC pp.251-64
Source: PubMed

ABSTRACT Functional neuronavigation with intraoperative 3-dimensional (3D) ultrasound may facilitate safer brain lesion resections than conventional neuronavigation.
In this study, functional magnetic resonance imaging (fMRI) and diffusion tensor tractography (DTT) were used to map eloquent areas. We assessed the use of fMRI and DTT for preoperative assessments and determined whether using these data together with 3D ultrasound during surgery enabled safer lesion resection.
We reviewed 51 consecutive patients with intracranial lesions in whom fMRI with or without DTT was used to map eloquent areas. To assess a possible impact of fMRI/DTT, we reviewed and analyzed the quality of the fMRI/DTT data, any change in therapeutic strategies, lesion to eloquent area distance (LEAD), extent of resection, and clinical outcome.
As a result of the fMRI/DTT mapping, the therapeutic strategies were changed in 4 patients. The median tumor residue for glioma patients was 11% (n = 33) and 0% for nonglioma lesions (n = 12). For gliomas, there was a significant correlation between decreasing LEAD and increasing tumor residue. Of the glioma patients, 42% underwent gross total resection (>or= 95%) and 12% suffered neurological worsening after surgery as a result of complications. Of glioma patients with an LEAD of <or= 5 mm, 24% underwent gross total resection and 10% experienced neurological deterioration.
This study demonstrates that preoperative fMRI and DTT had direct consequences for therapeutic strategies and indicates their impact on intraoperative strategies to spare eloquent cortex and tracts. Functional neuronavigation combined with intraoperative 3D ultrasound can, in most patients, enable resection of brain lesions with general anesthesia without jeopardizing neurological function.

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    Article: A systematic review of functional magnetic resonance imaging and diffusion tensor imaging modalities used in presurgical planning of brain tumour resection
    S Dimou, R A Battisti, D F Hermens, J Lagopoulos
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    ABSTRACT: Historically, brain tumour resection has relied up-on standardised anatomical atlases and classical mapping techniques for successful resection. While these have provid-ed adequate results in the past, the emergence of new technol-ogies has heralded a wave of less invasive, patient-specific techniques for the mapping of brain function. Functional magnetic resonance imaging (fMRI) and, more recently, dif-fusion tensor imaging (DTI) are two such techniques. While fMRI is able to highlight localisation of function within the cortex, DTI represents the only technique able to elucidate white matter structures in vivo. Used in conjunction, both of these techniques provide important presurgical information for thorough preoperative planning, as well as intraoperatively via integration into frameless stereotactic neuronavigational systems. Together, these techniques show great promise for improved neurosurgical outcomes. While further research is required for more widespread clinical validity and acceptance, results from the literature provide a clear road map for future research and development to cement these techniques into the clinical setup of neurosurgical departments globally.
    Neurosurgical Review 10/2012; · 2.04 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

3D ultrasound
 
brain lesions
 
conventional neuronavigation
 
decreasing LEAD
 
diffusion tensor tractography
 
fMRI/DTT data
 
functional magnetic resonance imaging
 
Functional neuronavigation
 
general anesthesia
 
gross total resection
 
intracranial lesions
 
intraoperative 3-dimensional
 
intraoperative 3D ultrasound
 
intraoperative strategies
 
median tumor residue
 
nonglioma lesions
 
preoperative fMRI
 
safer brain lesion resections
 
safer lesion resection
 
therapeutic strategies