Homocysteine and Internal Carotid Artery Occlusion in Ischemic Stroke

Department of Neurology and Research Institute of Clinical Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Jeonbuk, South Korea.
Journal of atherosclerosis and thrombosis (Impact Factor: 2.73). 09/2010; 17(9):963-9. DOI: 10.5551/jat.4796
Source: PubMed


Homocysteine is associated with increased arterial resistance and eventually causes luminal reduction. The purpose of the present study was to evaluate an association between the plasma concentration of total homocysteine (tHcy) and stenosis or occlusion of the internal carotid artery (ICA) in patients with ischemic stroke.
In total, 391 patients with ischemic stroke were evaluated from March 2007 to February 2008. The criterion for ICA stenosis or occlusion was set at greater than 50% luminal narrowing or complete obstruction in at least one ICA. Patients were assigned to one of three groups: normal ICA, ICA stenosis, and ICA occlusion.
ICA stenosis was found in 71 patients, whereas ICA occlusion in 22 patients (18.2% and 5.6%, respectively). Plasma tHcy was significantly higher in groups with ICA stenosis/occlusion with the highest value of ICA occlusion (14.6 ± 1.0 µmol/L, p = 0.025). A 1 µmol/L increase of tHcy showed an adjusted odds ratio of 1.12 (95% confidence intervals, 1.03-1.24, p=0.008) for ICA occlusion in a multivariate logistic model adjusted for all possible confounders, including age, sex, vascular risk factors, and stroke classifications.
Elevated levels of tHcy were significantly associated with the ICA occlusion, independent of vascular risk factors and stroke subtypes.

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    • "Homocysteine is an aminoacid byproduct of methionine metabolism, which aggravates artherosclerosis by damaging hemangioendothelial cells, increasing platelet aggregation through changing arachidonic acid metabolism, and decreasing anticoagulation factor activity.25 Increased homocysteine levels correlate with stenosis and occlusion of intracranial vessels in patients with ischemic stroke, and it also increases stroke risk.26,27 In the current study, no differences in homocysteine concentrations were found between cancer and noncancer patients with ischemic stroke. "
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    05/2014; 16(2):91-6. DOI:10.5853/jos.2014.16.2.91
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    ABSTRACT: Increased homocysteine levels can be responsible for arterial ischemic events, such as MI, stroke or peripheral vascular disease. Homocysteine is metabolized by two pathways: re-methylation and trans-sulfuration. Both involve folic acid, and vitamins B(6-12.) Several studies assumed that the folates and vitamins B supplementation or dietary source to normalize plasma homocysteine. But, even if tends to normalize homocysteine levels, lowering homocysteine by B-group vitamins and/or folates does not reduce cardiovascular risk. In fact, recent reports confirmed that hyper-homocysteinemia is not directly responsible for cardiovascular disease, but is merely present in individuals suffering for acute and/or chronic cardiovascular events, as a collateral finding. Reduced methylation potential (MP) [due to decreased S-adenosyl-methionine (AdoMet)/S-adenosyl-homocysteine (AdoHcy) ratio] induced by the elevated plasma homocysteine levels seems to be the true responsible for cardiovascular diseases (CVD). The pathogenic mechanisms responsible for CVD appear to be dependent of DNA hypomethylation inducing an inhibition of cyclin A transcription and a reduction of endothelial cells growth. But, other human studies performed in a wide range are requested.
    Journal of Thrombosis and Thrombolysis 07/2011; 32(1):82-8. DOI:10.1007/s11239-011-0550-4 · 2.17 Impact Factor
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    ABSTRACT: Gender is an important determinant for risk factors and outcomes of ischemic stroke. The aim of this study was to compare risk factors, and clinical outcomes after ischemic stroke between male and female patients.
    01/2014; 29(2):141. DOI:10.7180/kmj.2014.29.2.141
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