Comparisons of Plasma/Serum Micronutrients Between Okinawan and Oregonian Elders: A Pilot Study

Department of Neurology, Oregon Health & Science University, Portland, OR 97239-3098, USA.
The Journals of Gerontology Series A Biological Sciences and Medical Sciences (Impact Factor: 5.42). 10/2010; 65(10):1060-7. DOI: 10.1093/gerona/glq124
Source: PubMed


Certain micronutrients are protective against cognitive decline. We examined whether there is any uniform pattern of circulating micronutrients cross-culturally that are associated with successful cognitive aging. For the U.S. sample, we used the stored serum/plasma of 115 participants, collected in Oregon, USA. The Okinawa sample consisted of 49 participants selected using similar inclusion criteria as the Oregon sample, from the Keys to Optimal Cognitive Aging Project. All participants were aged 85 years and older without cognitive impairment. We found that the Okinawan elders used fewer vitamin supplements but had similar levels of vitamin B(12) and α-tocopherol, lower folate and γ-tocopherol, compared with Oregonian elders. That is, we did not find a uniform pattern of circulating micronutrients, suggesting that micronutrients other than those examined here or other lifestyle factors than nutrition could play an important role in achieving successful cognitive aging.

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Available from: Gene L Bowman, Sep 30, 2015
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    • "Recent genetics work has focused on genome-wide association studies and sequencing studies to explore specific areas of the genome implicated in human aging. Follow-up cohorts of older Okinawans have also been established for longitudinal study of particular age-related phenotypes, such as cognitive aging (Dodge et al., 2010; Katsumata et al., 2012). Intervention studies of the traditional Okinawan diet are also underway to assess biological effects on phenotypes reflective of healthy aging (Mano, Ishida, Ohya, Todoriki, & Takishita, 2009; Tuekpe, Todoriki, Sasaki, Zheng, & Ariizumi, 2006). "
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    ABSTRACT: In the second section, five chapters expose and clarify the known and hypoth-esized factors favoring healthy longevity, starting with genetic and environ-mental factors and comparing and contrasting populations in Okinawa and Hawaii (Chapter 7). Chapter 8 then underlines the importance of mobility in human aging, whereas Chapter 9 describes the physical and biological indi-cators of health for the oldest old in the United States. The final chapters in this section focus on genetics with an example of gene–gene interaction using Chinese data (Chapter 10) and an introduction to gene expression and longevity (Chapter 11).
    Healthy Longevity, A Global Approach, first edited by Jean-Marie Robine, Carol Jagger, and Eileen M. Crimmins, 11/2013: chapter Optimizing Human Health Span and Life Span Insights From Okinawa and Hawaii: pages 135 - 170; Springer Publishing Company, LLC., ISBN: 978-0-8261-0994-1
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    • "Data came from the Keys to Optimal Cognitive Aging Project (KOCOA), a prospective pilot cohort study of community-dwelling older people aged 80 years and older living in Okinawa, Japan. A detailed description of the recruitment process has been presented elsewhere [20] [21]. Briefly, researchers visited 22 senior centers, explained the study protocol, and asked them to participate in the study. "
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    ABSTRACT: We cross-sectionally examined which lipid profiles are associated with better cognitive function among those aged 80 and older, free of dementia (Clinical Dementia Rating ≤0.5), functionally independent, and community-dwelling. Our cohort consisted of 193 participants from the "Keys to Optimal Cognitive Aging (KOCOA) Project", a prospective cohort study in Okinawa, Japan. Higher low-density lipoprotein cholesterol levels and lower triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratios were associated with higher scores in memory performance after controlling for confounders. Further research is required to clarify the associations among LDL-C levels, TG/HDL-C ratios, and healthy cognitive aging.
    Journal of Alzheimer's disease: JAD 12/2012; 34(1). DOI:10.3233/JAD-121138 · 4.15 Impact Factor
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    • "The Okinawan elders used fewer vitamin supplements but had similar levels of vitamin B12 and α-tocopherol, compared with Oregonian elders. Thus the components leading to healthy cognitive ageing might include a variety of patterns that include a healthy diet, high physical activity, and social engagement [22]. Additionally, cognitive function, daily activity, and residential status, have been reported to affect nutritional intake of centenarians [23,24]. "
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    ABSTRACT: Ageing is a challenge for any living organism and human longevity is a complex phenotype. With increasing life expectancy, maintaining long-term health, functionality and well-being during ageing has become an essential goal. To increase our understanding of how ageing works, it may be advantageous to analyze the phenotype of centenarians, perhaps one of the best examples of successful ageing. Healthy ageing involves the interaction between genes, the environment, and lifestyle factors, particularly diet. Besides evaluating specific gene-environment interactions in relation to exceptional longevity, it is important to focus attention on modifiable lifestyle factors such as diet and nutrition to achieve extension of health span. Furthermore, a better understanding of human longevity may assist in the design of strategies to extend the duration of optimal human health. In this article we briefly discuss relevant topics on ageing and longevity with particular focus on dietary patterns of centenarians and nutrient-sensing pathways that have a pivotal role in the regulation of life span. Finally, we also discuss the potential role of Nrf2 system in the pro-ageing signaling emphasizing its phytohormetic activation.
    Immunity & Ageing 04/2012; 9(1):9. DOI:10.1186/1742-4933-9-9 · 3.54 Impact Factor
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