Malignant granular cell tumor: case report with a novel karyotype and review of the literature. Ann Diagn Pathol

Department of Pathology, St John Hospital and Medical Center, Detroit, MI 48236, USA.
Annals of diagnostic pathology (Impact Factor: 1.12). 08/2010; 14(4):273-8. DOI: 10.1016/j.anndiagpath.2009.08.004
Source: PubMed


Malignant granular cell tumor is a rare neoplasm reported to occur at various sites in the body. Histogenesis of these tumors is still vaguely understood; however, their metastatic potential and adverse prognosis is well-described in the literature. The histologic criteria of malignancy proposed by Fanburg-Smith et al are still debatable amongst pathologists, with metastasis being the sole criterion of malignancy with unanimous agreement. To our knowledge, no specific karyotype characterizes these tumors. Hence, the importance of detecting characteristic cytogenetic alterations in these tumors which might serve, in the future, as a possible aid in diagnosis or therapy. We report a new case of malignant granular cell tumor of the thigh with metastases to abdominal wall and both lungs causing severe dyspnea. Cytogenetic analysis demonstrated that 60% of cultured tumor cells display the following karyotype 46,XX,+X,dic(5;15).

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    • "A partial abruptio placenta was noted.28 Malignant granular cell tumor is a rare neoplasm reported to occur at various sites in the body.29 Granular Cell Tumors are rare mesenchymal soft tissue tumors that arise throughout the body and are believed to be of neural origin. "
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    Rare tumors 07/2011; 3(3):e33. DOI:10.4081/rt.2011.e33
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    • "Recently, many studies on GCTs have mainly focused on the recognition and correct preoperative diagnosis of this tumor in clinical practice, and on determining the histogenesis of this tumor by performing immunohistochemical, ultrastructural studies and cytogenetic analysis, but not on the management and clinical behavior of the tumor [9]. "
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