Malignant granular cell tumor: case report with a novel karyotype and review of the literature. Ann Diagn Pathol

Department of Pathology, St John Hospital and Medical Center, Detroit, MI 48236, USA.
Annals of diagnostic pathology (Impact Factor: 1.12). 08/2010; 14(4):273-8. DOI: 10.1016/j.anndiagpath.2009.08.004
Source: PubMed

ABSTRACT Malignant granular cell tumor is a rare neoplasm reported to occur at various sites in the body. Histogenesis of these tumors is still vaguely understood; however, their metastatic potential and adverse prognosis is well-described in the literature. The histologic criteria of malignancy proposed by Fanburg-Smith et al are still debatable amongst pathologists, with metastasis being the sole criterion of malignancy with unanimous agreement. To our knowledge, no specific karyotype characterizes these tumors. Hence, the importance of detecting characteristic cytogenetic alterations in these tumors which might serve, in the future, as a possible aid in diagnosis or therapy. We report a new case of malignant granular cell tumor of the thigh with metastases to abdominal wall and both lungs causing severe dyspnea. Cytogenetic analysis demonstrated that 60% of cultured tumor cells display the following karyotype 46,XX,+X,dic(5;15).

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    • "A partial abruptio placenta was noted.28 Malignant granular cell tumor is a rare neoplasm reported to occur at various sites in the body.29 Granular Cell Tumors are rare mesenchymal soft tissue tumors that arise throughout the body and are believed to be of neural origin. "
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    ABSTRACT: Cancer complicates approximately 0.1% of all pregnancies. Primary tracheal carcinoma is one of very rarely seen tumors and the rate of its being seen makes up approximately % 0.2 of all tumors of respiratory tract. The patient, 28 years old, who has 28-weeks-pregnant, was diagnosed with primary tracheal adenocystic carcinoma. Patient was made operation as thoracotomy and tracheal tumor was removed at the 28(th) week of pregnancy. Patient was delivered with sectio abdominale at the 39(th) week of pregnancy. Primary tracheal adenocystic carcinoma is very rarely seen tumors and it is the first tracheal ACC with pregnancy case in literature to have been detected and surgically treated during pregnancy. We discussed primary tracheal adenocystic carcinoma and tracheal tumors during pregnancy with literature.
    Rare tumors 07/2011; 3(3):e33. DOI:10.4081/rt.2011.e33
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    • "Recently, many studies on GCTs have mainly focused on the recognition and correct preoperative diagnosis of this tumor in clinical practice, and on determining the histogenesis of this tumor by performing immunohistochemical, ultrastructural studies and cytogenetic analysis, but not on the management and clinical behavior of the tumor [9]. "
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    ABSTRACT: Granular cell tumor (GCT) is a rare tumor that originates from the Schwann cells in the skin, soft tissues, and internal organs. Usually, GCTs are clinically benign, although malignant and multifocal forms are very rarely known to occur. Cases of GCT of the perianus are rare, and thus far, no study has reported synchronous GCTs of the perianus and the chest wall. We report a case of a 31-year-old woman with synchronous GCTs of the perianus and the chest wall to have a mind of consideration of the possibility of GCT in the differential diagnosis of perianal tumor.
    07/2011; 81(1):70-4. DOI:10.4174/jkss.2011.81.1.70
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    ABSTRACT: Fanburg-Smith et al. classified granular cell tumors (GCTs) using six criteria with high Ki-67 and p53 in malignant cases. We aim to refine their classification and reproduce their immunohistochemical findings. We, first, classified our 48 cases according to Fanburg-Smith criteria (37 benign, seven atypical, and four malignant), and performed Ki-67 and p53 on a sample of tumors. Then, we reclassified them into 44 benign and four with uncertain malignant potential (GCT-UMP) using only necrosis and/or mitoses. (1) According to Fanburg-Smith criteria: Malignant cases were significantly younger than benign and atypical ones; occurred predominantly in males; were significantly larger in size; and showed a higher Ki-67 expression but an insignificant difference in p53 staining. (2) Comparative findings: The four malignant cases according to Fanburg-Smith corresponded to our four cases with UMP. The seven atypical cases and our benign group shared similar means, except for age. None of these atypical cases recurred or metastasized. Despite its small number, our preliminary study showed similar selectivity of two more reproducible criteria (vs six) in the classification of cases of GCT with potential aggressive behavior, preserving a role for Ki-67 in difficult cases. However, metastases remain the sole definite criterion for malignancy.
    Pathology - Research and Practice 03/2011; 207(3):164-8. DOI:10.1016/j.prp.2010.12.007 · 1.40 Impact Factor
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