Stabilization of Curcumin by Complexation with Divalent Cations in Glycerol/Water System

Université de Toulouse-UMR 1010, Laboratoire de Chimie Agro-Industrielle, ENSIACET, INPT, INRA, 4 allée Emile Monso, 31432 Toulouse Cedex 4, France.
Bioinorganic Chemistry and Applications (Impact Factor: 1.66). 06/2010; 2010:292760. DOI: 10.1155/2010/292760
Source: PubMed

ABSTRACT The purpose of present study was to stabilize curcumin food pigment by its complexation with divalent ions like (Zn(2+), Cu(2+), Mg(2+), Se(2+)), in "green media" and evaluate its stability in vitro compared to curcumin alone. The curcumin complexes were prepared by mechanical mixture of curcumin and sulfate salts of each metal (metal : curcumin 1/1mol) into unconventional and nontoxic glycerol/water solvent. Two stoichiometry of complex were obtained, 1 : 1 and 1 : 2 (metal/curcumin), respectively. On evaluation of in vitro stability, all complexes were found to provide a higher stability from curcumin alone.

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