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The latest developments in the MATRICS process

Dr. Harvey is Professor of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
Psychiatry 06/2010; 7(6):49-52.
Source: PubMed

ABSTRACT The Measurement and Treatment Research to Improve Cognition in Schizophrenia Research process has led to several developments in the assessment of cognitive functioning for schizophrenia-treatment studies. The first development was the development of a consensus cognitive battery and a United States Food and Drug Administration-endorsed research design. Since the development of the cognitive battery, interest has been spurred in clinical trials in different countries and the development of co-primary functional outcomes measures for these. The MATRICS Consensus Cognitive Battery has been translated into 11 different languages and is being translated into even more. A study has been completed that compared the usefulness of multiple potential co-primary measures, suggesting that the University of California San Diego Performance-Based skills assessment, version II (UPSA-II) is the most suitable for studies conducted in English. These findings suggest that reliable performance-based measures that are easy to administer and highly correlated with cognitive functioning are now available for use in treatment studies.

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    • "The unmet medical need to find new approaches for the pharmacotherapy of the cognitive deficit in schizophrenia facilitated the establishment of MATRICS (Measurement and Treatment Research to Improve Cognition in Schizophrenia , www.matrics.ucla.com) and CNTRICS (Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia) initiatives (Carter, 2005; Carter and Barch, 2007; Carter et al., 2008; Harvey et al., 2010). As a result of the MATRICS collaboration a consensus of opinion on the core cognitive deficits in schizophrenia patients has emerged. "
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    • "The executive functioning measures in the consensus battery included tests of working memory (letter-number and spatial span tests), vigilance (continuous performance) and reasoning-problem solving (Neuropsychological Assessment Battery mazes test). MATRICS' purpose, in part, was to have a repeatable battery which could be used to assess interventions over a short course clinical trial (Buchanan, Keefe et al. 2010; Harvey, Green et al. 2010). As a result of this short term, global cognitive functioning assessment aim, MATRICS might best be considered a baseline battery, useful for cross-study comparison, but with a breadth and depth too narrow for the assessment of trajectories or able to meaningfully capture any one set of abilities completely. "
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