Article

Real-time, step-wise, electrical detection of protein molecules using dielectrophoretically aligned SWNT-film FET aptasensors.

Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, 790-784, Korea.
Lab on a Chip (impact factor: 5.67). 08/2010; 10(16):2052-6. DOI:10.1039/c005276k pp.2052-6
Source: PubMed

ABSTRACT Aptamer functionalized addressable SWNT-film arrays between cantilever electrodes were successfully developed for biosensor applications. Dielectrophoretically aligned SWNT suspended films made possible highly specific and rapid detection of target proteins with a large binding surface area. Thrombin aptamer immobilized SWNT-film FET biosensor resulted in a real-time, label-free, and electrical detection of thrombin molecules down to a concentration of ca. 7 pM with a step-wise rapid response time of several seconds.

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Keywords

Aptamer functionalized addressable SWNT-film arrays
 
biosensor applications
 
cantilever electrodes
 
Dielectrophoretically
 
films
 
seconds
 
target proteins
 
Thrombin aptamer immobilized SWNT-film FET biosensor
 
thrombin molecules
 

Taechang An