The polarization of immune cells in the tumour environment by TGF&UF062. Nat Rev Immunol

Yale University School of Medicine, 300 Cedar Street, TAC S-569, PO BOX 208011, New Haven, Connecticut 06520, USA.
Nature Reviews Immunology (Impact Factor: 33.84). 08/2010; 10(8):554-67. DOI: 10.1038/nri2808
Source: OAI

ABSTRACT Transforming growth factor-beta (TGFbeta) is an immunosuppressive cytokine produced by tumour cells and immune cells that can polarize many components of the immune system. This Review covers the effects of TGFbeta on natural killer (NK) cells, dendritic cells, macrophages, neutrophils, CD8(+) and CD4(+) effector and regulatory T cells, and NKT cells in animal tumour models and in patients with cancer. Collectively, many recent studies favour the hypothesis that blocking TGFbeta-induced signalling in the tumour microenvironment enhances antitumour immunity and may be beneficial for cancer therapy. An overview of the current drugs and reagents available for inhibiting TGFbeta-induced signalling and their phase in clinical development is also provided.

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Available from: Richard A Flavell, Aug 26, 2015
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    • "Understanding what is truly relevant for the abrogation of protective immunity in different cancers is needed for implementing more effective antitumor immunotherapies. Transforming growth factor-b (TGF-b) is a lymphocyte inhibitor secreted by multiple cells and frequently overexpressed in aggressive cancers (Flavell et al., 2010; Wrzesinski et al., 2007). Tumors induce dendritic cells (DCs) to secrete TGF-b, promoting regulatory T cell (Treg) expansion and indirect suppression of T cell effectors (Ghiringhelli et al., 2005; Hanks et al., 2013). "
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