Impact of cruciferous phytoalexins on the detoxification of brassilexin by the blackleg fungus pathogenic to brown mustard.
ABSTRACT The biotransformation of brassilexin, a potent phytoalexin produced by brown mustard (Brassica juncea L.), in the presence of various cruciferous phytoalexins was investigated. An important group of isolates of the fungal species Leptosphaeria maculans (Laird 2 and Mayfair 2), which is virulent to brown mustard, but not to canola, was used in this investigation. Brassilexin was detoxified by the fungus, but none of the phytoalexins seemed to affect substantially the rate of brassilexin detoxification; after 12 h of incubation, the amounts of brassilexin remaining in culture were as low as in controls, except in co-incubations with cyclobrassinin and sinalexin, which afforded intermediates that in solution oxidized spontaneously to brassilexin.
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ABSTRACT: A great number of structurally diverse natural products containing five-membered heterocyclic subunits, such as imidazole, oxazole, thiazole, and their saturated congeners, are abundant in nature. These naturally occurring metabolites often exhibit extensive and pharmacologically important biological activities. The latest progress in the isolation, biological activities, chemical synthetic studies, and biosynthetic pathways on these natural products is summarized in this review.Natural Product Reports 04/2011; 28(6):1143-91. · 10.72 Impact Factor