HIV-associated psoriasis: pathogenesis, clinical features, and management
ABSTRACT Psoriasis is a chronic papulosquamous skin disease that is thought to be a T-cell-mediated autoimmune disorder of keratinocyte proliferation. The association between psoriasis and HIV infection seems paradoxical, but insights into the role of T-cell subsets, autoimmunity, genetic susceptibility, and infections associated with immune dysregulation might clarify our understanding of the pathogenesis of psoriasis with HIV in general. HIV-associated psoriasis can be clinically confusing because several comorbid skin disorders in patients with HIV can mimic psoriasis. Phenotypic variants such as a Reiter's syndrome or fulminant erythroderma provide diagnostic clues to underlying immunodeficiency. The management of moderate and severe HIV-associated psoriasis is challenging, although patients typically improve with highly active antiretroviral therapy. Conventional systemic treatments might be contraindicated or need dose adjustment to avoid toxicity. New biological treatments in this setting are promising and warrant further study.
- SourceAvailable from: Larisa Poluektova[Show abstract] [Hide abstract]
ABSTRACT: The growing family of interleukin (IL)-12-like cytokines produced by activated macrophages and dendritic cells became the important players in the control of infections, development of inflammation, autoimmunity and cancer. However, the role of one of them-heterodimer IL-23, which consists of IL12p40 and the unique p19 subunit in HIV-1 infection pathogenesis and progression to AIDS, represent special interest. We overviewed findings of IL-23 involvement in control of peripheral bacterial pathogens and opportunistic infection, central nervous system (CNS) viral infections and autoimmune disorders, and tumorogenesis, which potentially could be applicable to HIV-1 and AIDS.Journal of Neuroimmune Pharmacology 09/2011; 7(1):95-112. DOI:10.1007/s11481-011-9315-2 · 3.17 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: RESUMEN La psoriasis es una enfermedad inflamatoria sistémica crónica que afecta la piel, las mucosas, las uñas y en algunos casos las articulacio-nes; en estudios actuales se afirma que además tiene importantes implicaciones metabólicas. Hasta hace algunos años se consideraba que la psoriasis en los adultos no afectaba la cara o, bien, que era leve y poco frecuente; sin embargo, en diversos estudios se ha corro-borado que es más común de lo que se esperaba y que es un marcador de psoriasis severa. Cuando las lesiones aparecen en la región centrofacial no es fácil realizar el diagnóstico diferencial con dermatitis seborreica, por lo que en algunos casos se utiliza el término de sebopsoriasis. Se comunica el caso de un paciente de 31 años de edad con diagnóstico de psoriasis centrofacial que recibió tratamiento con ungüento de tacrolimus a 0.1%. Las lesiones se aliviaron en tres semanas. Palabras clave: psoriasis facial, centrofacial, sebopsoriasis, tacrolimus. ABSTRACT Psoriasis is a chronic inflammatory systemic disease that may affect skin, mucous membranes, nails and joints. Recent data indicate that psoriasis is also associated with metabolic disorders. Until recently it was considered that facial psoriasis was infrequent, but now it has been reported that facial involvement is more common than previously thought and that is a marker of severe psoriasis. When lesions occur in the central aspect of the face, a differential diagnosis of seborrheic dermatitis is not easy; in this case is correct to use the term sebopsoriasis. We report the case of a 31 year-old male patient with centrofacial psoriasis who was treated with 0.1% topic tacrolimus twice daily, showing relieve of lesions after 3 weeks.
- [Show abstract] [Hide abstract]
ABSTRACT: LED degradation was investigated using cathodoluminescence (CL), electron-beam-induced current (EBIC) and device parameter extraction using a two-diode model. After electrical stress, the nonradiative recombination current increases, and the electroluminescence (EL) intensity at constant current bias decreases. The average EBIC and CL intensities also decrease. There is a good correlation between CL, EL and EBIC measurements. The two-diode model can reasonably model the LED degradation behaviourPhysical and Failure Analysis of Integrated Circuits, 1999. Proceedings of the 1999 7th International Symposium on the; 02/1999