Candida invasion and influences in smoking patients with multiple oral leucoplakias - a retrospective study
Department of Oral and Maxillofacial Surgery, Chang Gung Memorial Hospital-Kaohsiung Memorial Center, Kaohsiung, Taiwan. Mycoses
(Impact Factor: 2.24).
09/2011; 54(5):e377-83. DOI: 10.1111/j.1439-0507.2010.01927.x
Treating patients with multiple oral leucoplakias (MOLs) who smoke is more difficult and complicated than treating those with single oral leucoplakia (SOL). Removing the aetiological factors causing MOL can effectively prevent its recurrence. The aim was to study the infection by and influences of Candida in smoking patients with MOLs. A retrospective study was conducted on 136 smoking patients who had clinicopathological OLs. Among these patients, 73 lesions in 31 patients were MOLs, while 105 patients had SOLs. All patients were treated by complete resection. All specimens were tested for epithelial dysplasia, and stained with periodic acid-Schiff reagent. The rate of MOL concurrence with candidal infection was higher than that of SOLs. The incidence of Candida associated with MOLs was higher for recurrent than for non-recurrent lesions. The disease-free time was shorter in MOL patients with candidal infection. Moreover, MOLs with candidal infection were more likely to have an increasing ratio to combine with epithelial dysplasia. Candida is an important risk factor in smoking patients with MOLs. Microscopic and fungal examinations of those lesions should permit a detailed diagnosis in such patients and for long-term predictive assessments.
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Available from: Suzana C O M de Sousa
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ABSTRACT: Oral leukoplakias (OL) are potentially malignant lesions that are typically white in color. Smoking is considered a risk factor for developing OL, and dysplastic lesions are more prone to malignant transformation. The aim of this study was to describe the clinical features observed in dysplastic and non-dysplastic OL in both smokers and non-smokers. A total of 315 cases of OL were retrieved and separated into either dysplastic or non-dysplastic lesions, and these cases were further categorized as originating in either smokers or non-smokers. Frequencies of the type of OL lesion, with respect to whether the patients smoked, were established. The results demonstrated that 131 cases of OL were dysplastic (74 smokers and 57 non-smokers), and 184 were non-dysplastic (96 smokers and 88 non-smokers). For OL cases in smokers for which information about alcohol consumption was also available (84 cases), the results revealed no significant difference in the amount of dysplastic and non-dysplastic lesions. Dysplastic lesions were more frequent in male smokers and in non-smoking females. The median age of smokers with cases of OL was significantly lower than in non-smokers; the lowest median ages were observed for female smokers with dysplastic OL. The most frequent anatomical sites of dysplastic lesions were the floor of the mouth in smokers and the tongue in non-smokers. Dysplastic lesions in smokers were significantly smaller than non-dysplastic lesions in non-smokers. Being a male smoker, being female, being younger, and having smaller lesions were associated with dysplastic features in OL. These clinical data may be important for predicting OL malignant transformation.
Brazilian oral research 09/2012; 26(6). DOI:10.1590/S1806-83242012005000024 · 0.94 Impact Factor
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ABSTRACT: We aimed to examine if smoking is an independent predictor of oral candidiasis (OC) among HIV-1 infected persons.
The cross-sectional part of this study evaluated 631 adult dentate HIV-1 seropositive persons examined for OC from 1995–2000 at the University of North Carolina Hospitals in Chapel Hill, NC. In the second part, from the above sample, a total of 283 individuals who were free of HIV-associated oral diseases at baseline were followed up for 2 years to assess incident OC events. Data collected from medical record review, interview questionnaires, and clinical examinations were analyzed using chi-squared tests and t-tests. Logistic regression models were developed for prevalent OC employing the likelihood ratio test, whereas Poisson regression models were developed for assessing cumulative incidence of OC. These models included a variety of independent variables to adjust for confounding.
Thirteen percent of participants had OC only; 4.6% had OC with Oral Hairy Leukoplakia; and 69.7% had neither. Smoking was associated with OC in all models [prevalent OC – current smokers: logistic regression – Odd ratio (95% CI) = 2.5 (1.3, 4.8); Incident OC – current smokers: Poisson regression (main effects model) – Incidence rate ratio (95% CI) = 1.9 (1.1, 3.8)]. Other Poisson regression models suggested evidence for effect modification between CD4 cell count and incident OC by smoking.
Smoking is an independent risk factor for the development of OC in HIV-1 infected persons, and the risk of OC is modified by CD4 cell count which measures strength of the immune system.
Journal of Oral Pathology and Medicine 12/2012; 42(4). DOI:10.1111/jop.12019 · 1.93 Impact Factor
Available from: Mirsada Hukic
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ABSTRACT: The aim of the study was to determine presence of Candida species in oral cavity and to investigate their relation with the smoking habit. This prospective study included 140 healthy respondents (75 male and 65 female) divided into two groups according to the age: group I (from 18 to 30 years) and group II (from 31 to 60 years). In 77 (55%) cases the respondents were smokers. Group I included 37 (52.8%) and group II 40 (57.1%) smokers. There were significantly more male smokers, 49 (62.3%). Candida spp. were identified in 40 (29%) healthy respondents (carriers). The most frequently isolated was Candida albicans. Patients with the presence of oral Candida were smokers in 33 (82.5%) cases, while patients without Candida were smokers in 44 (44%) cases. Smoking has an influence on oral colonization with Candida species. Both have a bad influence on oral health.
Medicinski glasnik 08/2013; 10(2):397-9. · 0.20 Impact Factor
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