Article

Retrotransposition and Structural Variation in the Human Genome

Department of Molecular and Human Genetics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX 77030, USA.
Cell (Impact Factor: 33.12). 06/2010; 141(7):1110-2. DOI: 10.1016/j.cell.2010.06.014
Source: PubMed

ABSTRACT New assays are revealing that the diploid human genome contains extensive amounts of structural variation. Genome-wide approaches described in three papers in this issue (Beck et al., 2010; Huang et al., 2010; Iskow et al., 2010) paint a dynamic portrait of our genome, revealing a prominent role for repetitive sequences in shaping its structural variation.

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