Article
V(D)J recombination: Born to be wild.
Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Seminars in Cancer Biology (impact factor:
6.47).
08/2010;
20(4):254-60.
DOI:10.1016/j.semcancer.2010.06.002
pp.254-60
Source: PubMed
- Citations (2)
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Cited In (0)
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Article: V(D)J recombination: links to transposition and double-strand break repair.
Cold Spring Harbor Symposia on Quantitative Biology 02/1999; 64:161-7. -
Article: Autophosphorylation-dependent targeting of calcium/ calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl- D-aspartate receptor.
[show abstract] [hide abstract]
ABSTRACT: Activation and Thr286 autophosphorylation of calcium/calmodulindependent kinase II (CaMKII) following Ca2+ influx via N-methyl-D-aspartate (NMDA)-type glutamate receptors is essential for hippocampal long term potentiation (LTP), a widely investigated cellular model of learning and memory. Here, we show that NR2B, but not NR2A or NR1, subunits of NMDA receptors are responsible for autophosphorylation-dependent targeting of CaMKII. CaMKII and NMDA receptors colocalize in neuronal dendritic spines, and a CaMKII.NMDA receptor complex can be isolated from brain extracts. Autophosphorylation induces direct high-affinity binding of CaMKII to a 50 amino acid domain in the NR2B cytoplasmic tail; little or no binding is observed to NR2A and NR1 cytoplasmic tails. Specific colocalization of CaMKII with NR2B-containing NMDA receptors in transfected cells depends on receptor activation, Ca2+ influx, and Thr286 autophosphorylation. Translocation of CaMKII because of interaction with the NMDA receptor Ca2+ channel may potentiate kinase activity and provide exquisite spatial and temporal control of postsynaptic substrate phosphorylation.Journal of Biological Chemistry 09/1998; 273(33):20689-92. · 4.77 Impact Factor
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Keywords
adaptive immune response
adaptive immunity
particular transposon's integration step
raw material
transposon mobility
two steps
V(D)J recombination
