Article

Novel candidate substrates of AMP-activated protein kinase identified in red blood cell lysates.

Institute of Cell Biology, ETH Zurich, Zurich, Switzerland.
Biochemical and Biophysical Research Communications (impact factor: 2.48). 07/2010; 398(2):296-301. DOI:10.1016/j.bbrc.2010.06.084 pp.296-301
Source: PubMed

ABSTRACT AMPK is a metabolic stress-sensing kinase with important functions for red blood cell (RBC) survival. By using a proteomic approach, we identified putative AMPK targets in hemoglobin-depleted lysates of RBC, including metabolic enzymes, cytoskeletal proteins and enzymes involved in the oxidative stress response. These data tie in with the phenotypic observations of AMPKalpha1-deficient RBC and provide reference for future studies.

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Keywords

AMPKalpha1-deficient RBC
 
data tie
 
enzymes
 
functions
 
future studies
 
hemoglobin-depleted lysates
 
metabolic enzymes
 
metabolic stress-sensing kinase
 
oxidative stress response
 
phenotypic observations
 
proteomic approach
 
RBC