Psychiatric Symptoms in Adults With Down Syndrome and Alzheimer's Disease
ABSTRACT Changes in psychiatric symptoms related to specific stages of dementia were investigated in 224 adults 45 years of age or older with Down syndrome. Findings indicate that psychiatric symptoms are a prevalent feature of dementia in the population with Down syndrome and that clinical presentation is qualitatively similar to that seen in Alzheimer's disease within the general population. Psychiatric symptoms related to Alzheimer's disease vary by the type of behavior and stage of dementia, but do not seem to be influenced by sex or level of premorbid intellectual impairment. Some psychiatric symptoms may be early indicators of Alzheimer's disease and may appear prior to substantial changes in daily functioning. Improvements in understanding the progression of dementia in individuals with Down syndrome may lead to improved diagnosis and treatment.
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ABSTRACT: The author describes the development of a digital road network database for the Region of Waterloo, Ont. from National Topographic Service 1:50000 digital map files. The system was developed for use in conjunction with a positionally based emergency location code assigned to rural properties in the Region, and is being extended to other areas. Real-time dispatching and routeing of emergency service vehicles from a digital database have been demonstrated for over 10000 nodes and 13000 road segments. The database is being enhanced to incorporate a variety of attribute data which can be used by all emergency service agencies. A full set of network functions is included for dispatching, routeing network flow, simulation and training, etc. The road data can be structured to accommodate arbitrarily large networks by using an embedded hypergraph model. Other potential applications are based on use of automatic vehicle location as an onboard facility in conjunction with the databaseVehicle Navigation and Information Systems Conference, 1989. Conference Record; 10/1989
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ABSTRACT: Depression has been frequently reported in individuals with Down Syndrome (DS). The aim of this article is to provide a comprehensive, critical review of the clinically relevant literature concerning depression in DS, with a focus on epidemiology, potential risk factors, diagnosis, course characteristics and treatment. We searched the PUBMED database (January 2011) using the keywords ("Depressive Disorder [MESH]" OR "Depression [MESH]" OR "depress* [All Fields]") AND ("Down Syndrome [MESH]" OR "Down syndrome [All Fields]" OR "Down's syndrome [All Fields]"). Review articles not adding new information, single case reports and papers focusing on subjects other than depression in DS were excluded. The PUBMED search resulted in 390 articles, of which 30 articles were finally included. Recent information does not support earlier suggestions of an increased prevalence of depression in DS compared to other causes of Intellectual Disability (ID). However, individuals with DS show many vulnerabilities and are exposed to high levels of stressors that could confer an increased risk for the development of depression. Apart from general risk factors, several potential risk factors are more specific for DS, including smaller hippocampal volumes, certain changes in neurotransmitter systems, deficits in language and working memory, attachment behaviours and frequently occurring somatic disorders. Protective factors might play a role in reducing the vulnerability to depression. The diagnosis of depression in DS is mainly based upon observable characteristics, and therefore, the use of modified diagnostic criteria is advised. Although several common treatments, including antidepressants, electroconvulsive therapy and psychotherapy seem effective, there is evidence of undertreatment of depression in DS. There are important limitations to our current clinical knowledge of depression in DS. Future studies should include systematic evaluations of pharmacotherapeutic and psychotherapeutic interventions.Research in developmental disabilities 03/2011; 32(5):1432-40. DOI:10.1016/j.ridd.2011.02.010 · 4.41 Impact Factor
- Journal of developmental and behavioral pediatrics: JDBP 07/2011; 32(7):548-58. DOI:10.1097/DBP.0b013e31822182e0 · 2.12 Impact Factor