Mortality Patterns Among Paducah Gaseous Diffusion Plant Workers

Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY 40202, USA.
Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine (Impact Factor: 1.63). 07/2010; 52(7):725-32. DOI: 10.1097/JOM.0b013e3181e48ee0
Source: PubMed


To determine whether Paducah Gaseous Diffusion Plant workers had mortality patterns that differed from the general US population and to investigate whether mortality patterns were associated with job title or workplace exposures.
A retrospective occupational cohort mortality study was conducted on 6759 workers. Standardized mortality ratio analyses compared the cohort with the referent US population. Internal comparisons producing standardized rate ratios were conducted by job title, metal exposure, and cumulative internal and external radiation exposures.
Overall mortality and cancer rates were lower than the referent population, reflecting a strong healthy worker effect. Individual not significant standardized mortality ratios and standardized rate ratios were noted for cancers of the lymphatic and hematopoietic tissue.
Although relatively low exposures to radiation and metals did not produce statistically significant health effects, no significant elevations for lymphatic and hematopoietic cancers were consistent with previous studies of nuclear workers.

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Available from: Susan Muldoon, Oct 24, 2014
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    • "Reference Country Work type Uranium Solubility Study design, max period of follow-up (years) No. of workers No. of all deaths/ cancer cases ICD in use No. of lung/L/NHL/HD/MM/K cancers ¶ No. of CSD/ IHD/CVD cases Part A. Studies of uranium-processing workers ( n ϭ 19) [1] Boice et al. 2007 USA 1 NU S/IS * CM, 25 450 186/48 9 24/1/1/NA/0/1 Ͼ 65/ Ͻ 65/9 [2] Boice et al. 2008 USA 1 NU S/IS * CM, 26 718 220/56 9 18/3/1/0/0/3 Ͼ 63/ Ͻ 63/12 [3] Pinkerton et al. 2004 USA 1 NU S/IS * CM, 58 1485 810/184 9 78/5/ Ͼ 4/4/ Ͻ 8/4 † 362/236/ Ͻ 69 [4] Zablotska et al. 2013b Canada 1 NU S/IS * CM/CI, 49 2472 1097/266 9 78/6/7/NA/NA/6 514/346/71 [5] Canu et al. 2010 France 2/3 NU/EU/DU/RPU S/IS CM, 37 2709 411/193 9 – 10 48/7/8/NA/3/5 101/NA/NA [6] Canu et al. 2011 France 2/3 NU/EU/DU/RPU S/IS CM, 38 2897 460/214 9 – 10 53/ Ͻ 21/ Ͻ 21/ Ͻ 21/ Ͻ 21/NA NA/NA/NA [7] Dupree et al. 1987 USA 2 NU S/IS * CM, 36 995 429/74 8 Ͻ 21/NA/ Ͻ 6/ Ͻ 6/ Ͻ 6/NA Ͻ 227/ Ͼ 159/NA [8] Dupree et al. 1995 USA 2/4 NU S/IS * NCCM, 46 1574 787/787 8 787/NA/NA/NA/NA/NA NA/NA/NA [9] Guseva Canu et al. 2012 France 2/3 NU/EU/DU/RPU S/IS CM, 38 2897 NA/NA 9 – 10 NA/NA/NA/NA/NA/NA 111/48/31 [10] Chan et al. 2010 USA 3 "
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    • "Other published Oak Ridge GD plant studies evaluated only radiation exposures, though they considered mercury, nickel and trichloroethylene exposures as potential confounders (Anderson et al., 2007; Loomis and Wolf, 1996; Yiin et al., 2009). Paducah plant-specific JEM focused only exposure to metals , including arsenic, hexavalent chromium, nickel, beryllium and uranium (Chan et al., 2010; Hahn, 2005). Authors applied a similar method to group workstations but ranking of exposure levels was performed on five-point scale, solely considering exposure intensity. "
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