New Technique Using Combined Pulsed Dye Laser and Fractional Resurfacing for Treating Facial Angiofibromas in Tuberous Sclerosis

Laser & Skin Surgery Center of New York, New York, New York 10016, USA.
Lasers in Surgery and Medicine (Impact Factor: 2.61). 07/2010; 42(5):357-60. DOI: 10.1002/lsm.20939
Source: PubMed

ABSTRACT Tuberous sclerosis (TS) is a well-described genetic disorder that is classically associated with up to hundreds of facial angiofibromas. Due to the progressive nature of the skin lesions and the early clinical presentation, a safe and effective technique for treating these disfiguring skin lesions is needed.
We report a combinatorial technique for treating the angiofibromas of TS. We present a case series of three TS patients treated with this technique combining pinpoint electrosurgery, pulsed-dye laser treatment, and ablative fractional resurfacing (AFR).
In all presented cases, improvement in the number and appearance of facial angiofibromas and erythema is noted. No scarring or adverse events were reported.
The technique of electrosurgery, pulsed-dye laser treatment, and AFR represents a new and safe therapeutic option for treating facial angiofibromas associated with TS.

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    ABSTRACT: Please cite this article as: Dill PE, Bernardis GD, Weber P, Lösch U, Topical everolimus for facial angiofibromas in the tuberous sclerosis complex. A first case report, Pediatric Neurology (2014), doi: 10.1016/j.pediatrneurol.2014.02.016. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.