Article

Acinetobacter baumannii outer membrane protein A induces dendritic cell death through mitochondrial targeting.

Department of Microbiology, Kyungpook National University School of Medicine, Daegu, 700-422, Republic of Korea.
The Journal of Microbiology (impact factor: 1.1). 06/2010; 48(3):387-92. DOI:10.1007/s12275-010-0155-1 pp.387-92
Source: PubMed

ABSTRACT Acinetobacter baumannii outer membrane protein A (AbOmpA) is a potential virulence factor that induces epithelial cell death, but its pathologic effects on the immune system have yet to be determined. The present study investigated the pathologic events occurring in dendritic cells (DCs) exposed to a cytotoxic concentration of AbOmpA. AbOmpA induced early-onset apoptosis and delayed-onset necrosis in DCs. AbOmpA targeted the mitochondria and induced the production of reactive oxygen species (ROS). ROS were directly responsible for both apoptosis and necrosis of AbOmpA-treated DCs. These results demonstrate that the AbOmpA secreted from A. baumannii induces DC death, which may impair T cell biology to induce adaptive immune responses against A. baumannii.

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Keywords

A. baumannii
 
A. baumannii induces DC death
 
AbOmpA induced early-onset apoptosis
 
AbOmpA-treated DCs
 
Acinetobacter baumannii outer membrane protein
 
apoptosis
 
cytotoxic concentration
 
dendritic cells
 
impair T cell biology
 
induce adaptive immune responses
 
induces epithelial cell death
 
mitochondria
 
potential virulence factor
 
reactive oxygen species