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Mycobacterium tuberculosis Microbiologic and Clinical Treatment Outcomes in a Randomized Trial of Immediate versus CD4(+)-Initiated Antiretroviral Therapy in HIV-Infected Adults with a High CD4(+) Cell Count

Department of Medicine, University of California, San Francisco, CA, USA.
Clinical Infectious Diseases (Impact Factor: 9.42). 08/2010; 51(3):359-62. DOI: 10.1086/654799
Source: PubMed

ABSTRACT In a prospective randomized, controlled trial in Uganda comparing the efficacy of antiretroviral therapy during tuberculosis therapy with the efficacy of tuberculosis therapy alone in HIV-infected patients with tuberculosis who have a CD4(+) cell count >350 cells/microL, it was found that antiretroviral therapy did not accelerate microbiologic, radiographic, or clinical responses to tuberculosis therapy: 18% of participants had sputum smears positive for Mycobacterium tuberculosis after 5 months of tuberculosis therapy, despite having had negative culture results. Trial registration. ClinicalTrials.gov identifier: NCT00078247 .

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