Depression treatment and its impact upon the quality of life in patients with diabetes type 2 - The Croatian study

Department of Psychiatry, University Hospital Centre Zagreb, 10000 Zagreb, Croatia.
Psychiatria Danubina (Impact Factor: 1.3). 06/2010; 22(2):231-5.
Source: PubMed


Depression is prevalent in patients with type 2 diabetes and affects quality of life. The prevalence of depression in the sample of Croatian patients with diabetes is 32.2%. The main aim of the investigation was to evaluate the effect of antidepressant treatment on quality of life and metabolic control in depressed diabetic patients.
In the sample we randomized 60 diabetic outpatients with optimally controlled diabetes and with depression. The efficacy of 50 mg sertraline per day treatment was tested by the MADRAS questionnaire in a 24-week period, where the patients controlled themselves. Changes in the quality of life as the consequences of treatment of depression were tested by the QLSQ questionnaire for the quality of life follow-up.
The MADRAS scale results, measuring the changes in the degree of depression, showed substantial improvement of condition throughout the whole treatment. The first eight weeks of treatment presented statistically high significance in examinees in all the groups of chronic somatic diseases. The QLSQ scale results for measuring the quality of life showed marked improvement. Statistically significant changes occurred during the first eight weeks of treatment. Two patients withdrew their consent before starting medication and 13 dropped out later in the study. Treatment of depression with sertraline in chronic somatic patients did not induce changes in the HbA1c.
that the prevalence of depression in patients with somatic diseases is several times higher than in general population. Treatment of depression with antidepressants from the group of selective serotonin reuptake inhibitors (sertraline) causes improvement of depressive symptoms and increases the quality of life in diabetic patients. Treatment of depression has no impact upon the values control parameters in these patients.

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    • "Antidepressant treatment brings about improvement of depressive symptoms, prevents recurrences and increases the quality of life in diabetic patients. Some clinical studies show the association of antidepressant effects and improvement of glycemic control (Lustman et al. 2007, Abrahamian et al. 2009), but reduction of depressive symptoms upon antidepressive treatment was not accompanied by simultaneous improvement of glycoregulation , according to the results of other studies (Lustman et al. 1997, Georgiades et al. 2007, Filipčić et al. 2010). Patients with T2DM and concomitant depression are a subset with a worse clinical course and health outcome. "
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