Article

Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

National Cancer Institute, Bethesda, Maryland 20852, USA.
American journal of epidemiology (Impact Factor: 4.98). 07/2010; 172(1):94-106. DOI: 10.1093/aje/kwq121
Source: PubMed

ABSTRACT Upper gastrointestinal (GI) cancers of the stomach and esophagus have high incidence and mortality worldwide, but they are uncommon in Western countries. Little information exists on the association between vitamin D and risk of upper GI cancers. This study examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and upper GI cancer risk in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 1,065 upper GI cancer cases and 1,066 age-, sex-, race-, and season-of blood draw-matched controls from 8 prospective cohort studies. In multivariate-adjusted models, circulating 25(OH)D concentration was not significantly associated with upper GI cancer risk. Subgroup analysis by race showed that among Asians, but not Caucasians, lower concentrations of 25(OH)D (<25 nmol/L) were associated with a statistically significant decreased risk of upper GI cancer (reference: 50-<75 nmol/L) (odds ratio = 0.53, 95% confidence interval: 0.31, 0.91; P trend = 0.003). Never smokers with concentrations of <25 nmol/L showed a lower risk of upper GI cancers (odds ratio = 0.55, 95% confidence interval: 0.31, 0.96). Subgroup analyses by alcohol consumption produced opposing trends. Results do not support the hypothesis that interventions aimed at increasing vitamin D status would lead to a lower risk of these highly fatal cancers.

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    • "Although a number of studies have investigated associations between serum vitamin D levels and various cancers (Garland and Garland, 1980; Chen et al, 2007; Li et al, 2007; Abbas et al, 2008; Ahn et al, 2008; Abnet et al, 2010; Jenab et al, 2010; Stolzenberg- Solomon et al, 2010), little epidemiologic data for vitamin D and liver cancer are available, despite the important role of the liver in metabolising the circulating form of vitamin D. Supporting a possible association, vitamin D has been shown to inhibit liver carcinogenesis in cell lines and several animal models (Ghous et al, 2008), for example, vitamin D has been shown to reduce the number of chromosomal aberrations and double-strand breaks (Saha et al, 2001) as well as prevent cellular proliferation (Pourgholami et al, 2000; Caputo et al, 2003). For liver disease, results from existing epidemiologic studies, each modest in size, are mixed. "
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