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    ABSTRACT: Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practices with significant morbidity, mortality and socioeconomic burden. Its prevalence and incidence are on the rise due to an increase in population age. AF has complex electrophysiological mechanisms, etiology and natural history and thus management is a challenge. More than 80% of cases in AF are related to an underlying structural heart disease. Stroke and congestive heart failure remain the most significant complications of AF. Depending on the patient’s symptoms, duration and type of AF, structural heart disease and non-cardiac comorbidities, several management options are currently available. Asymptomatic AF carries similar risks as symptomatic AF. Rate control approach in majority of cases especially elderly patients is reasonable. Novel anticoagulation agents have shifted the paradigm in stroke prevention and management in patients with AF. Catheter ablation of paroxysmal AF in patients with no to minimal structural heart disease who have failed at least one antiarrhythmic agent appears reasonable.
    09/2014; DOI:10.1016/j.ehj.2014.03.004
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    ABSTRACT: Genetic factors play an important role in the pathogenesis of atrial flutter (AF). Although mutation in KCNQ1 has been widely correlated with AF, the mechanism by which mutation promotes AF remains poorly understood. The purpose of this study was to investigate the proarrhythmic effect of V241F KCNQ1 mutation in human atrium using the electrophysiological model of human atrium. Using 2D and 3D cardiac electrophysiological models that incorporate the Courtemanche human atrial model, we simulated electrical conduction through atrial tissue and compared spiral wave dynamics under the wild-type and V241F KCNQ1 conditions. In 2D and 3D simulation, V241F KCNQ1 showed a stable and persistent wave without spiral break-up, whereas the wild-type wave was less stable, resulting in early self-termination. According to the results, we concluded that compared to the wild type, the electrical activity of the V241F KCNQ1 mutation is more likely to sustain spiral wave.
    Progress in Biophysics and Molecular Biology 09/2014; 116(1). DOI:10.1016/j.pbiomolbio.2014.09.001 · 3.38 Impact Factor
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    ABSTRACT: The aim was to assess atrial fibrillation (AF) and vulnerability in Wolff-Parkinson-White (WPW) syndrome patients using two-dimensional speckle tracking echocardiography (2D-STE).
    PLoS ONE 11/2014; 9(11):e108315. DOI:10.1371/journal.pone.0108315 · 3.53 Impact Factor

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May 17, 2014