Article

RB's original CIN?

Department of Pediatrics, Stanford University, Stanford, California 94305, USA.
Genes & development (Impact Factor: 12.64). 07/2010; 24(13):1329-33. DOI: 10.1101/gad.1948010
Source: PubMed

ABSTRACT The retinoblastoma tumor suppressor RB is the downstream mediator of a cellular pathway that is thought to prevent cancer by controlling the ability of cells to enter or exit the cell cycle in G0/G1. Recently, however, accumulating evidence has suggested that RB, its family members p107 and p130, and their partners, the E2F family of transcription factors, may have important cellular functions beyond the G1/S transition of the cell cycle, including during DNA replication and at the transition into mitosis. In this issue of Genes & Development, three studies demonstrate a critical role for RB in proper chromosome condensation, centromeric function, and chromosome stability in mammalian cells, and link these cellular functions of RB to tumor suppression in mice. Here we discuss how transcriptional and post-transcriptional mechanisms under the control of the RB pathway ensure accurate progression through mitosis, thereby preventing cancer development.

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    • "Another protein, the retinoblastoma (RB) tumour suppressor, has been also related to CIN. RB tumour suppressor is the downstream mediator of a cellular pathway that is thought to prevent cancer by controlling the ability of cells to enter or exit the cell cycle in G 0 /G 1 [38]. "
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    • "These findings stress pRB's importance as a node for mediating CDK–cyclin-derived signals to various downstream processes. The mode of operation may be indirect, via the regulation of transcription of E2F-depen- dent genes, or direct, via binding and sequestration of, e.g., chromatin modifiers like histone methyl transferases or DNA repair-related proteins like BRCA1 (Aprelikova et al, 1999; Sage and Straight, 2010). pRB is conserved and can also be found in higher plants. "
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