"One drug that appears to be effective in this respect is off-label aprepitant, a neurokinin 1 (NK-1) receptor antagonist that was approved in 2003 for the prevention of chemotherapy-induced nausea and vomiting, both acute and delayed. The main ligand of the NK-1 receptor, substance P, has emerged as an important mediator of the induction and maintenance of pruritus
. Furthermore, increased levels of NK-1 have been reported in the keratinocytes of patients with chronic pruritus
[Show abstract][Hide abstract] ABSTRACT: Introduction
Paraneoplastic pruritus is defined as pruritus that occurs before or during the natural evolution of a hematologic disease. The reported prevalence is 30% in patients with Hodgkin’s lymphoma. The severity of this pruritus has a very negative impact on patients’ quality of life. Very few studies have been made to examine the efficacy of pharmacological treatments for this type of pruritus. One drug that appears to be effective in this respect is off-label aprepitant, a neurokinin 1 receptor antagonist.
A 20-year-old Caucasian woman presented with lateral neck nodes, sweating, and pruritus and was diagnosed with stage IIB nodular sclerosis Hodgkin’s lymphoma. Throughout this period during the disease the pruritus was ever-present. Improvement was achieved with some of the chemotherapy treatments, but the symptom returned when the various treatments were withdrawn due to disease progression or poor tolerance. In the middle of the seventh year, she was admitted to our hospital with uncontrolled pruritus that resulted in severe lesions due to scratching. In response, aprepitant (off-label) 80mg/day was added to the chemotherapic treatment of the pruritus, after studying the various treatment options. She reported a score of 9 on a visual analogue scale for the pruritus, and a score of 3 on the Eastern Cooperative Oncology Group performance status scale of performance status. After two weeks of treatment with aprepitant, she reported a score of 5 on the visual analogue scale for the pruritus, and this improved to a score of 4 in a month, which allowed her to lead a better quality of life, with an Eastern Cooperative Oncology Group performance status score between 1 and 2.
Several cases and case series have been reported on the use of aprepitant for paraneoplastic pruritus, but none have referred to its use for Hodgkin’s lymphoma. A prospective study was carried out to evaluate the efficacy of this drug in refractory pruritus secondary to Sezary syndrome, and other authors have studied the effectiveness of aprepitant against pruritus, secondary to biological therapy with erlotinib. In our case report, treatment was started with daily doses of aprepitant 80mg. Pruritus improvement appeared to be attributable exclusively to the administration of aprepitant.
Journal of Medical Case Reports 09/2014; 8(1):300. DOI:10.1186/1752-1947-8-300
[Show abstract][Hide abstract] ABSTRACT: A new method of measuring and extracting bias dependent noise
parameters for GaAs MESFETs and PHEMTs is presented. This technique only
requires noise figure and S-parameter measurements over frequency. This
eliminates the need for time-consuming traditional sourcepull
measurements and facilitates rapid noise parameter extraction. This
technique makes the extraction of bias-dependent noise models of MESFETs
and PHEMTs practical, for the first time, in a production test
ARFTG Conference Digest, 1998. Computer-Aided Design and Test for High-Speed Electronics. 52nd; 02/1998
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.