Article

Benzofuran-substituted urea derivatives as novel P2Y(1) receptor antagonists.

Department of Chemistry, Infectious Diseases Centre for Excellence in Drug Discovery, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
Bioorganic & medicinal chemistry letters (impact factor: 2.65). 07/2010; 20(14):4104-7. DOI:10.1016/j.bmcl.2010.05.072 pp.4104-7
Source: PubMed

ABSTRACT Benzofuran-substituted urea analogs have been identified as novel P2Y(1) receptor antagonists. Structure-activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation.

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Keywords

ADP-mediated platelet activation
 
analogs
 
benzofuran moieties
 
Benzofuran-substituted urea analogs
 
potency