Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells

Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China.
Biochemical and Biophysical Research Communications (Impact Factor: 2.28). 07/2010; 398(1):62-7. DOI: 10.1016/j.bbrc.2010.06.033
Source: PubMed

ABSTRACT Recently, salidroside (p-hydroxyphenethyl-beta-d-glucoside) has been identified as one of the most potent compounds isolated from plants of the Rhodiola genus used widely in traditional Chinese medicine, but pharmacokinetic data on the compound are unavailable. We were the first to report the cytotoxic effects of salidroside on cancer cell lines derived from different tissues, and we found that human breast cancer MDA-MB-231 cells (estrogen receptor negative) were sensitive to the inhibitory action of low-concentration salidroside. To further investigate the cytotoxic effects of salidroside on breast cancer cells and reveal possible ER-related differences in response to salidroside, we used MDA-MB-231 cells and MCF-7 cells (estrogen receptor-positive) as models to study possible molecular mechanisms; we evaluated the effects of salidroside on cell growth characteristics, such as proliferation, cell cycle duration, and apoptosis, and on the expression of apoptosis-related molecules. Our results demonstrated for the first time that salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells and may be a promising candidate for breast cancer treatment.

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Available from: Xiaolan Hu, Nov 25, 2014
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    • "It has exhibited a wide range of pharmacological properties, including anti-aging, anti-oxidation, anti-inflammatory, anti-fatigue, anti-depressant activities, antiviral effects, hepatoprotective, neuroprotective, and cardiovascular protective characteristics (Zhang et al., 2007, 2010; Wang et al., 2009). Recent studies have also shown that salidroside may prevent the growth of leukemia, stomach adenocarcinoma and parotid carcinoma (Hu et al., 2010), and may also significantly decrease neovascular reactions (De Bock et al., 2004). Despite its attractive pharmacological activities, the therapeutic potential of salidroside has been significantly restricted by its short biological half-life and poor oral bioavailability (Fan et al., 2007). "
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