Article

Consumption of polyphenol concentrate with dietary fructo-oligosaccharides enhances cecal metabolism of quercetin glycosides in rats.

Division of Food Science, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.
Nutrition (impact factor: 3.03). 03/2011; 27(3):351-7. DOI:10.1016/j.nut.2010.02.002 pp.351-7
Source: PubMed

ABSTRACT We verified the hypothesis that the consumption of polyphenol concentrate (PC), rich in quercetin and its glycosides (36 g/100 g), in association with different dietary fiber matrices, that is, an easily fermentable fructo-oligosaccharides (FOS) or non-fermentable cellulose (CEL), causes a disparate adaptive response of the cecal microbial activity in rats. This in turn facilitates further utilization of biologically active polyphenolic compounds, which are not, as usual, digested in the foregut.
Four-week experimental feeding of male Wistar rats consisted of diets containing 5% FOS or CEL, as a source of dietary fiber, with or without 0.3% addition of PC.
Positive changes in rat cecum were observed resulting from the ingestion of an FOS-containing diet, such as decreased pH and increased the production of short-chain fatty acids in the digesta, compared with a CEL-containing diet. The addition of PC to the FOS diet did not eliminate the positive effects of the latter, except for a slight increase in cecal pH and a decrease in microbial glycolytic activity. However, a simultaneous increase in the cecal butyrate pool was also observed. An adaptation process of the microflora enzymatic system to dieting with PC and FOS was proven in further enhanced susceptibility of rutin (quercetin 3-O-glucorhamnoside), hyperoside (quercetin 3-O-galactoside), and quercitrin (quercetin 3-O-rhamnoside) to hydrolysis by the cecal digesta solution.
Especially when consumed together, PC and FOS are important dietary factors affecting the susceptibility of quercetin glycosides to microbial metabolism in the cecum. The intensification of the hydrolysis of quercetin glycosides by dietary treatments leads also to the increased metabolism of quercetin itself.

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    Article: Identification of microbial metabolites derived from in vitro fecal fermentation of different polyphenolic food sources.
    Margherita Dall'Asta, Luca Calani, Marianna Tedeschi, Lucia Jechiu, Furio Brighenti, Daniele Del Rio
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Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

biologically active polyphenolic compounds
 
cecal digesta solution
 
cecal microbial activity
 
CEL-containing diet
 
dietary fiber
 
different dietary fiber matrices
 
disparate adaptive response
 
fermentable fructo-oligosaccharides
 
Four-week experimental
 
increased metabolism
 
male Wistar rats
 
microbial glycolytic activity
 
microbial metabolism
 
microflora enzymatic system
 
non-fermentable cellulose
 
Positive changes
 
quercetin glycosides
 
short-chain fatty acids
 
slight increase
 
turn facilitates