Impact of Genotype and Ethnicity onin the prevalence of
Metabolic Syndrome associated with Chronic Hepatitis C
Thomas Sersté1,2, Marcel Nkuize2, Marc Van Gossum2, Marijycke Reynders3, Olivier Vandenberg 3and
Jean Pierre Mulkay2
1Hepatology, Hospital Beaujon, Clichy, France,
2 Hepato-Gastroenterology, Hospital Saint-Pierre, Bruxelles, Belgique
3 Microbiology, Molecular Biology Group, Hospital Saint-Pierre, Bruxelles, Belgique
Background & Aim:
HCV infection is associated with an increased risk of metabolic disorder especially in
patients with genotype 1 and 4. Ethnical distribution in patients with chronic hepatitis
C is linked to the genotype. The aim of this study was to consider test the eventual
association between Metabolic Syndrome (MS) and Ethnicity and/or genotype in a
large cohort of chronic hepatitis C patients.
Patients and Methods:
This study included all consecutive patients with CHC, followed up in ourthe
department of hepato-gastroenterology in our institute between January 2002 and
September 2008. Demographic data and all components of the MS were collected.
According to their genotype and the metabolic profile, patients were classified into
groups: patients with genotype 1/4 compared to those with genotype 2/3 and patients
with MS compared withto patients without MS.
A total of 454 CHC patients were studied. Two hundred ninety-four had genotype 1/4
(64.8%), 160 (35.2%) patients had genotype 2/3. The prevalence of the MSmetabolic
syndromein the studied population was 11.5%. Patients with Genotype 1/4 were
significantly older (50.4 ± 12.8 vs 44.6 ±10.6 years, P≤0.001). There were many
Black Africans in the genotype 1/4 group (32.0 % vs 1.2 %, P≤0.0001). The
prevalence of the Metabolic Syndrome was higher in patients with genotype 1/4 than
in patients with genotype 2/3 (11.7% vs 5.0%, P=0.03). Genotype 1/4 was associated
independently with the presence of the MS (OR, 11.3 ; 95% CI: 1.4–89, P=0.02).
Patients with MS were older than those without (53.8 ± 11.6 vs 47.9 ±12.5 years,
respectively, P=.005). Genotypes 1/4 were found more frequently in patients with MS
(96% vs 66.5%, respectively, P= 0.0001). There was a statistical difference
inbetween the ethnical distribution according to the presence of the MS (Black
Africans: 48.0 % in the presence of MS vs 18.8% in its absence; P= 0.0001).
The presence of the MS was associated independently with genotype 1/4 (OR,
14.68; 95% CI: 1.89–113.7, P=0.02).
The prevalence of MS in Chronic Hepatitis C is independently associated with
genotype ¼. Ethnicity is not independently linked to the MS.