Article

[Association of the polymorphism of synaptobrevins/vesicle-associated membrane proteins 8 gene with coronary heart disease in Chinese Han population].

Department of Cardiovascular Medicine, Shenzhen Shajing Affiliated Hospital, Guangzhou Medical University, Shenzhen, Guangdong, 518104 PR China.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 06/2010; 27(3):329-32. DOI:10.3760/cma.j.issn.1003-9406.2010.0.020 pp.329-32
Source: PubMed

ABSTRACT To investigate the association of synaptobrevins/vesicle-associated membrane proteins 8 (VAMP8) gene rs1010 polymorphism with coronary heart disease (CHD) in Chinese Han population.
The allele and genotype frequencies of the VAMP8 gene rs1010 locus in 185 CHD patients and 149 controls were analyzed by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing.
There was polymorphism of the VAMP8 gene rs1010 locus in the studied population. The distribution of VAMP8 genotypes was in Hardy-Weinberg equilibrium. The frequency of the A allele in the CHD group was significantly higher than that in control (67.3% vs 53.0%, P< 0.05). Multiple logistic regression analysis showed that genotypes AA and AG were independent risk factors of coronary heart disease. The odds ratio (OR) of (AA+AG) genotype versus GG genotype was 1.969,95% CI: 1.032-3.755.
The VAMP8 rs1010 polymorphism was associated with CHD risk in Chinese Han population, the A allele might serve as a genetic risk factor of coronary heart disease.

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Keywords

185 CHD patients
 
AA+AG
 
Chinese Han population
 
coronary heart disease
 
DNA sequencing
 
genetic risk factor
 
genotype frequencies
 
genotypes AA
 
GG genotype
 
P< 0.05). Multiple logistic regression analysis
 
polymerase chain reaction-restriction fragment length polymorphism
 
studied population
 
VAMP8 gene rs1010 locus
 
VAMP8 genotypes
 
VAMP8 rs1010 polymorphism