Quality assessment of different marketed brands of Dasamoolaristam, an Ayurvedic formulation
ABSTRACT Arista is a classical Ayurvedic preparation that is typically used as a digestive and cardiotonic. The present Investigation evaluated five different brands of Dasamoolaristam available in the market as per WHO and Indian Pharmacopoeial specifications. Various physicochemical parameters such as alcohol-soluble extractive, water-soluble extractive, total ash, acid-insoluble ash, total solid, and alcohol content were determined. The present investigation reveals that all the preparations contain acceptable levels of alcohol (less than 12% v/v). However, the preparations were found to contain unacceptable limits of microbial load although all showed the absence of Escherichia coli, Salmonella species, and Staphylococcus aureus.
- International journal of Ayurveda research 04/2010; 1(2):132. DOI:10.4103/0974-7788.64397
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ABSTRACT: Herbal formulations have reached extensive acceptability as therapeutic agents for several diseases. The development of authentic analytical methods which can reliably profile the phytochemical composition, including quantitative analyses of marker/bioactive compounds and other major constituents, is a major challenge to scientists. Standardization is an important step for the establishment of a consistent biological activity, a consistent chemical profile, or simply a quality assurance program for production and manufacturing of herbal drugs. WHO specific guidelines for the assessment of the safety, efficacy and quality of herbal medicines as a prerequisite for global harmonization are of utmost importance. An overview covering various techniques employed in extraction and characterization of herbal medicines as well as herbal nanomedicines standardization is reported. In addition, phytosomes increased bioavailability, bhasma as a metal nanocarrier drug delivery system, potential of metabolomics in the development of improved phytotherapeutic agents, DNA based molecular markers in distinguishing adulterants, and SCAR markers for authentication and discrimination of herbs from their adulterants are reported. The extraction of high-valued herbal compounds using microwave–assisted extraction and supercritical phase extraction technology followed by the standardization utilizing various spectroscopic, chromatographic and thermogravimetric techniques individually and/or in combination has been discussed in relation to herbal drugs. Capillary electrophoresis and polarographic techniques contributions towards standardization of herbal drugs is also reported. Nanotechnology based Chinese herbal drugs possess improved solubility and enhanced bioavailability.
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ABSTRACT: Sandhana kalpana (biomedical fermented formulations) are one of the best dosage forms of Ayurveda in practice since thousands of years. In order to prepare these medicaments, certain sets of conditions are prearranged, which lead to fermentation. Thus, products bequeath with self-generated ethyl alcohol, which potentiate these preparations (Asava-Arishta), pharmaceutically and therapeutically. Commonly, medicinal and commercial components of these formulations are prompting many researchers to contribute in manufacturing, quality control, safety, and efficacy of these formulations. To cope up with this, literature related to Asava-Arishta has been surveyed from the Vedic period to recent publications of Government of India, ie, Ayurvedic Formulary of India, and presented briefly here. In this review paper, we have discussed pioneering facts such as nature and amount of carbohydrate, type of containers, optimum temperature, variety and relevance of initiator of fermentation, manufacturing, regulatory rules, and business aspects of Asava-Arishta. After going through this basic information, any academician or researcher may show a way to further strengthen this dosage form.07/2011; 32(3):408-17. DOI:10.4103/0974-8520.93925