Grosse SDAssessing cost-effectiveness in healthcare: history of the $50,000 per QALY threshold. Exp Rev Pharmacoecon Outcomes Res 8: 165-178

National Center on Birth Defects & Developmental Disabilities, Centers for Disease Control and Prevention (CDC), 1600 Clifton Raod NE, Atlanta, GA 30333, USA. .
Expert Review of Pharmacoeconomics & Outcomes Research (Impact Factor: 1.67). 04/2008; 8(2):165-78. DOI: 10.1586/14737167.8.2.165
Source: PubMed

ABSTRACT Cost-effectiveness analyses, particularly in the USA, commonly use a figure of $50,000 per life-year or quality-adjusted life-year gained as a threshold for assessing the cost-effectiveness of an intervention. The history of this practice is ill defined, although it has been linked to the end-stage renal disease kidney dialysis cost-effectiveness literature from the 1980s. The use of $50,000 as a benchmark for assessing the cost-effectiveness of an intervention first emerged in 1992 and became widely used after 1996. The appeal of the $50,000 figure appears to lie in the convenience of a round number rather than in the value of renal dialysis. Rather than arbitrary thresholds, estimates of willingness to pay and the opportunity cost of healthcare resources are needed.

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    • "In a comprehensive review , Grosse puts the initial mention of the $ 50 000 threshold in 1972 at the initiation of Medicare coverage for patients with end - stage renal disease ; the first article using a cost - effectiveness threshold in 1992 followed by the publication of the first studies using this threshold in 1995 ; and ( informal ) adoption of the threshold between 1996 and 1998 ( Grosse , 2008 "
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