A calcified sellar lesion

Department of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin, CSC, Madison, Wisconsin 53792, USA.
Journal of Clinical Neuroscience (Impact Factor: 1.38). 07/2010; 17(7):897, 956. DOI: 10.1016/j.jocn.2009.09.012
Source: PubMed
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    ABSTRACT: A 50-year-old male with acromegalic features presented with a pituitary stone in a growth hormone-secreting adenoma. Endocrinological examination showed "low growth hormone acromegaly." The serum growth hormone level responded to the thyrotropin-releasing hormone test and was not suppressed by oral glucose loading. Neuroimaging revealed an adenoma including a large calcification (pituitary stone) located in the right lateral wing. The adenoma with stone was totally removed by transsphenoidal surgery. The patient regained almost normal response of serum growth hormone. Histological examination showed the stone was composed of thick calcification surrounded by necrotic adenoma tissue and chronic hemorrhage. Large intratumoral pituitary stone is very rare, although calcification is sometimes observed in the adenoma capsule. The long history of this disease and previous apoplexy within the tumor may have caused the pituitary stone in this patient.
    Neurologia medico-chirurgica 08/2000; 40(7):383-6. DOI:10.2176/nmc.40.383 · 0.72 Impact Factor
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    ABSTRACT: A 42-year-old male presented with a prolactin-producing pituitary adenoma with an atypical radiological appearance. The tumor was incidentally found by magnetic resonance imaging, which demonstrated a cystic tumor in the enlarged and partially empty sella turcica. Computed tomography revealed the tumor was surrounded by calcification with an egg-shell appearance. The serum prolactin level was 37 ng/ml. The operative finding was a calcified shell-containing cystic tumor. Immunohistochemical staining revealed prolactin-positive cells. The combination of the unusual calcification, and enlarged and partially empty sella was considered to be a sequela of spontaneous degeneration of the tumor.
    Neurologia medico-chirurgica 11/1996; 36(10):729-32. DOI:10.2176/nmc.36.729 · 0.72 Impact Factor
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    ABSTRACT: Though craniopharyngioma remains the most common sellar suprasellar tumor with calcification, it can be seen very rarely in pituitary adenomas and Rathke's cleft cysts. Appreciation of the pattern of calcification in a sellar suprasellar lesion can give a clue to the nature of the lesion. The authors describe a 53-yearold male with a cystic sellar suprasellar lesion and curvilinear calcification that was managed by successful transsphenoidal surgery. The present case highlights the occurrence of calcification in a pituitary adenoma and the importance of recognizing the calcification pattern for pre-operative diagnosis of sellar suprasellar lesions that can help plan the surgical strategy and management.
    Turkish neurosurgery 08/2008; 18(3):232-5. · 0.58 Impact Factor