Colon neoplasias are presently the third most common cancer type. Its treatment is still associated with high risk of complications, thus emphasizing the need to design new treatment strategies. The ingestion of probiotics and prebiotics, or the combination of both (symbiotics), represents a new therapeutic choice. In front of the importance among qualitative and quantitative balance in intestinal microbiota for human's health and with the purpose to evaluate the application of probiotics and prebiotics, this study tries to approach the importance of these in both the prevention and treatment of colon cancer.
A study was conducted on scientific databases (Medline, Lilacs, PubMed, Ovid, SciELO), and a review was made of recent scientific articles in the literature, from 2003 to 2008. Additional informations were taken from sites in the internet.
Studies point out the inverse relation between the consumption of probiotics and prebiotics in colon cancer diagnosis through various action mechanisms, including: immune response stimulation, reduction in inflammation, for directly inhibiting the formation of tumor cells and for converting pre-carcinogenic substances into carcinogenic ones.
Through this literature review, it was possible to achieve positive answers as regards the use of probiotics and prebiotics in carcinogenesis, which can be adequately recommended.
[Show abstract][Hide abstract] ABSTRACT: Beneficial effects of prebiotics like inulin and fructo-oligosaccharides (FOS) have been proven in health and nutrition. Yacon (Smallanthus sonchifolius), an Andean crop, contains FOS (50-70 % of its dry weight) and, therefore, is considered a prebiotic. Commercial FOS can up-regulate total secretory IgA (S-IgA) in infant mice, prevent infection with Salmonella in swine or enhance immune response for Salmonella vaccine in a mouse model. Previously, we found that administration of yacon root flour regulates gut microbiota balance and has immunomodulatory effects without inflammatory responses. The aim of the present paper is to analyse if yacon prevents enteric infection caused by a strain of Salmonella enteritidis serovar Typhimurium (S. Typhimurium) in a mouse model. BALB/c mice were supplemented with yacon flour (45 d), challenged with S. Typhimurium and killed to study pathogen translocation, total and specific IgA production by ELISA, presence of IgA and other cytokines and Toll-like receptor 4 (TLR4) and clustor of differentiation 206 (CD206) receptors positive cells by immunofluorescence and histological changes. Yacon flour administration had a protective effect from 15 to 30 d of treatment. We found a peak of total S-IgA production without translocation of the pathogen for these periods. At 30 d, there was an increase in IL-6 and macrophage inflammatory proteins-1α+ cells and expression of the receptors CD206 and TLR4. Yacon flour did not have incidence in pathogen-specific S-IgA production. Longer periods (45 d) of administration had no protective effect. Therefore, yacon can prevent enteric infection caused by S. Typhimurium when given up to 30 d; this effect would be mediated by enhancing non-specific immunity, such as total S-IgA, that improves the immunological intestinal barrier.
The British journal of nutrition 11/2012; 109(11):1-9. DOI:10.1017/S0007114512004230 · 3.45 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Effect of various concentrations of NSAIDs (Non-steriodal anti-inflammatory drugs) on growth of commercial probiotic preparations (A, B, C, and D) were observed by agar well diffusion assay found that sample A followed by B found to be more resistant against all NSAIDs. Comparative evaluation of commercial probiotic preparations was carried out on the basis of physical parameter, antibiotic sensitivity, antimicrobial activity and hydrophobicity assay. Effect of temperature, pH and bile tolerance of samples were carried out in MRS medium and growth was determined by counting cfu value of appropriate dilution after 2h, 4h, and 24h. Antibiotic sensitivity was carried out by disc diffusion assay. Antimicrobial activity was tested using E. coli, S. aureus, P. mirabilis and E. ficalis by in-vitro agar well diffusion method and zone of inhibition was recorded after 24 h. Hydrophobicity assay were carried out using SAT and MATH techniques. Sample B was found to be the most promising probiotic product with respect to physical parameters and antimicrobial activity while sample D followed by B found to be more antibiotic resistant and higher hydrophobicity percentage.
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