Association of plasma B-type natriuretic peptide levels with obesity in a general urban Japanese population: the Suita Study.

The Department of Atherosclerosis and Diabetes, National Cardiovascular Center, Osaka, Japan.
Endocrine Journal (Impact Factor: 2.02). 01/2010; 57(8):727-33. DOI: 10.1507/endocrj.K10E-067
Source: PubMed

ABSTRACT The inverse association between plasma B-type natriuretic peptide (BNP) levels and body mass index (BMI) has been reported in Western populations. Here we analyzed the relationship between plasma BNP and obesity in a general urban Japanese population. We recruited 1,759 subjects without atrial fibrillation or history of ischemic heart disease aged 38-95 years (mean age +/- standard deviation 64.5 +/- 10.9 years, 56.1% women, mean BMI 22.8 +/- 3.1 kg/m(2)) from the participants in the Suita Study between August 2002 and December 2003. In multivariable regression analyses adjusted for age, systolic blood pressure, pulse rate, serum creatinine, left ventricular hypertrophy in ECG, the inverse relationships between BNP levels and BMI (kg/m(2)) was found in both sexes (both p<0.001). Multivariable-adjusted mean plasma BNP levels in the group of BMI<18.5, 18.5< or =BMI< 22, 22< or =BMI<25, and 25< or =BMI were 23.4, 17.9, 14.0 and 13.0 pg/mL, respectively (trend p<0.001). The negative association of body fat (percentage and mass), skin fold thickness, or waist circumference with BNP levels was observed the negative associations in both sexes (p<0.01). Among the obesity indices, body fat mass is most tightly associated with BNP. In conclusion, plasma BNP was inversely associated with obesity related markers such as body fat mass, skinfold thickness and waist circumferences after adjusted for relevant covariates in a Japanese population.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Japan Aerospace Exploration Agency has introduced a terascale SMP cluster type parallel supercomputer system as the main compute engine of Numerical Simulator III for aerospace science and engineering purposes. The computing system, called CeNSS, has 9.3Tflop/s peak performance and 3.6TB user memory, about 1,800 scalar processors are used. It also has a mass storage consisting of 57TB disk and 620TB tape library, and a visualization system is tightly integrated to the computing system. In this paper, after reviewing the history of the Numerical Simulator project, we describe the system configuration of NS-III. Next, we mention the performance issues on the CeNSS. Finally, illustrating some examples of the recent application results performed on the JAXA NS-III, we discuss the emerging trends and the future challenges in aerospace CFD.
    High Performance Computing and Grid in Asia Pacific Region, 2004. Proceedings. Seventh International Conference on; 08/2004
  • [Show abstract] [Hide abstract]
    ABSTRACT: Eurasian perch (Perca fluviatilis) is a promising aquaculture candidate, but the growth performance of this non-domesticated species may be negatively affected by its stress responsiveness to intensive culture conditions. To evaluate this potential problem, juvenile Eurasian perch were exposed to a standardized handling stressor twice a week for an 8-week period. A similar study was conducted on domesticated rainbow trout (Oncorhynchus mykiss) for comparison of intra- and inter-specific differences. The stressed fish of both species showed lower body growth than the non-stressed control fish, however, the final mean body mass was 35.4% lower in the stressed Eurasian perch than in the non-stressed controls, compared to 22.8% difference between the two groups in rainbow trout. The stress responsiveness was examined by comparing the post-stress cortisol and glucose levels in repeatedly stressed fish and fish exposed to the stressor only once. The cortisol stress response in both species strongly indicated a habituation to the repeated stressor. Thus, repeatedly stressed Eurasian perch reached maximum cortisol levels of 130 ng/mL after 0.5 h compared to 200 ng/mL in the fish stressed once, while considerably smaller differences in cortisol levels were shown between the repeatedly and single stressed rainbow trout. Rainbow trout also showed lower post-stress glucose levels in the repeatedly stressed fish compared to the single stressed fish. In contrast, the glucose levels in both groups of Eurasian perch increased abruptly after stress treatment and remained elevated at approximately 19 mM for 6 h; levels were three times as high as the peak levels 3 h post-stress in rainbow trout. Together, the habituation of the stress response shown in both species did not eliminate the growth difference found in the repeatedly stressed fish versus the control fish. Further, the lower growth performance of Eurasian perch compared to rainbow trout could partly be due to the increased energy consumption in the more stress responsive Eurasian perch.
    Comparative Biochemistry and Physiology - Part A Molecular & Integrative Physiology 08/2005; 141(3):353-8. DOI:10.1016/j.cbpb.2005.06.006 · 2.37 Impact Factor
  • Source
    Journal of Hypertension 01/2011; 29:e287. DOI:10.1097/00004872-201106001-00812 · 4.22 Impact Factor
Show more