R spider: a network-based analysis of gene lists by combining signaling and metabolic pathways from Reactome and KEGG databases

Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Institute for Bioinformatics and Systems Biology, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany.
Nucleic Acids Research (Impact Factor: 8.81). 07/2010; 38(Web Server issue):W78-83. DOI: 10.1093/nar/gkq482
Source: PubMed

ABSTRACT R spider is a web-based tool for the analysis of a gene list using the systematic knowledge of core pathways and reactions in human biology accumulated in the Reactome and KEGG databases. R spider implements a network-based statistical framework, which provides a global understanding of gene relations in the supplied gene list, and fully exploits the Reactome and KEGG knowledge bases. R spider provides a user-friendly dialog-driven web interface for several model organisms and supports most available gene identifiers. R spider is freely available at

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