Article

Facilitating pharmacokinetic studies in children: a new use of dried blood spots.

School of Pharmacy, De Montfort University, Leicester, UK.
Archives of Disease in Childhood (impact factor: 2.88). 06/2010; 95(6):484-7. DOI:10.1136/adc.2009.177592
Source: PubMed

ABSTRACT Pharmacokinetic data are used to develop dosing regimens for medicines. The dose regimens of many drugs administered to children have historically been based on pharmacokinetic data generated in adults. The 'adult' dose was simply adjusted to the child's body weight or surface area. This practice is potentially unsafe and not acceptable to drug regulatory agencies. Obtaining pharmacokinetic data in children is beset with ethical issues and technical challenges as pharmacokinetic studies require repeated measurement of drug levels in blood. Dried blood spot (DBS) samples used in conjunction with population pharmacokinetic modelling techniques is one potential method for performing pharmacokinetic studies in children. In this article, we review the DBS technique for performing pharmacokinetic studies and highlight issues that still need to be addressed to establish DBS as a method for performing pharmacokinetic studies in children.

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    Article: Direct analysis of dried blood spots coupled with mass spectrometry: concepts and biomedical applications.
    Julien Déglon, Aurélien Thomas, Patrice Mangin, Christian Staub
    [show abstract] [hide abstract]
    ABSTRACT: Because of the emergence of dried blood spots (DBS) as an attractive alternative to conventional venous plasma sampling in many pharmaceutical companies and clinical laboratories, different analytical approaches have been developed to enable automated handling of DBS samples without any pretreatment. Associated with selective and sensitive MS-MS detection, these procedures give good results in the rapid identification and quantification of drugs (generally less than 3 min total run time), which is desirable because of the high throughput requirements of analytical laboratories. The objective of this review is to describe the analytical concepts of current direct DBS techniques and to present their advantages and disadvantages, with particular focus on automation capacity and commercial availability. Finally, an overview of the different biomedical applications in which these concepts could be of major interest will be presented.
    Analytical and Bioanalytical Chemistry 06/2011; 402(8):2485-98. · 3.78 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

'adult' dose
 
child's body weight
 
DBS
 
DBS technique
 
dosing regimens
 
Dried blood spot
 
drug levels
 
drugs
 
ethical issues
 
Obtaining pharmacokinetic data
 
Pharmacokinetic data
 
pharmacokinetic studies
 
population pharmacokinetic modelling techniques
 
potential method
 
surface area
 
technical challenges