Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice.

Wolfgang Eck, Anthony I Nicholson, Hanswalter Zentgraf, Wolfhard Semmler, Sönke Bartling

Applied Physical Chemistry, University of Heidelberg, Heidelberg, Germany.

Journal Article: Nano Letters (impact factor: 9.99). 05/2010; 10(7):2318-22. DOI: 10.1021/nl101019s

Abstract

Antibody-conjugated gold nanoparticles have been applied as a biologically targeted contrast agent in live mice for one of the most widely used medical imaging methods, X-ray computed tomography. Such nanoprobes directed toward the CD4 receptor lead to distinctly enhanced X-ray contrast of peripheral lymph nodes. This study demonstrates the general feasibility of biologically specific X-ray imaging in living animals and discusses basic requirements for the use of nanoparticles as a targeted X-ray contrast agent.

Source: PubMed

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Keywords

Antibody-conjugated gold nanoparticles
 
CD4 receptor lead
 
discusses basic requirements
 
general feasibility
 
medical imaging methods
 
peripheral lymph nodes
 
targeted X-ray contrast agent