Article

Associations Between Anthropometry, Cigarette Smoking, Alcohol Consumption, and Non-Hodgkin Lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Department of Epidemiology and Biostatistics, School of Public Health and Health Services, George Washington University, Washington, DC, USA.
American journal of epidemiology (Impact Factor: 4.98). 06/2010; 171(12):1270-81. DOI: 10.1093/aje/kwq085
Source: PubMed

ABSTRACT Prospective studies of lifestyle and non-Hodgkin lymphoma (NHL) are conflicting, and some are inconsistent with case-control studies. The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was used to evaluate risk of NHL and its subtypes in association with anthropometric factors, smoking, and alcohol consumption in a prospective cohort study. Lifestyle was assessed via questionnaire among 142,982 male and female participants aged 55-74 years enrolled in the PLCO Trial during 1993-2001. Hazard ratios and 95% confidence intervals were calculated using Cox proportional hazards regression. During 1,201,074 person-years of follow-up through 2006, 1,264 histologically confirmed NHL cases were identified. Higher body mass index (BMI; weight (kg)/height (m)(2)) at ages 20 and 50 years and at baseline was associated with increased NHL risk (P(trend) < 0.01 for all; e.g., for baseline BMI > or =30 vs. 18.5-24.9, hazard ratio = 1.32, 95% confidence interval: 1.13, 1.54). Smoking was not associated with NHL overall but was inversely associated with follicular lymphoma (ever smoking vs. never: hazard ratio = 0.62, 95% confidence interval: 0.45, 0.85). Alcohol consumption was unrelated to NHL (drinks/week: P(trend) = 0.187). These data support previous studies suggesting that BMI is positively associated with NHL, show an inverse association between smoking and follicular lymphoma (perhaps due to residual confounding), and do not support a causal association between alcohol and NHL.

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    • "Studies conducted in Connecticut and among women living in Iowa, for instance, have suggested decreased risks of NHL associated with higher consumption of red wine [33] [44]. Higher consumption of wine has also been inversely associated with NHL in a large population-based case-control study [45], but other studies suggest null or elevated risks [10] [20] [40]. Red wine is a source of a variety of phytochemicals, including resveratrol which has antiinflammatory properties and may aid in the inhibition of tumor proliferation [46], including for human lymphoma cells specifically [47]. "
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