A deathly DNase activity for dicer.

Sloan-Kettering Institute, Department of Developmental Biology, 1275 York Ave, Box 252, New York, NY 10065, USA.
Developmental Cell (Impact Factor: 12.86). 05/2010; 18(5):692-4. DOI: 10.1016/j.devcel.2010.05.004
Source: PubMed

ABSTRACT Recently reporting in Science, Nakagawa et al. describe an unexpected role for Dicer in chromosome fragmentation during apoptosis in C. elegans. They find that cleavage of DCR-1 by the caspase CED-3 redirects its regulatory activity, by destroying its dsRNase activity while activating an intrinsic DNase activity.

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: In this review, the pathways involving small RNAs are provided followed by a new and updated network that illustrates their interplay with diverse cellular mechanisms in Caenorhabditis elegans. The RNA silencing pathways are now recognized as key factors that connect together the many variations in biological processes, including transcriptional gene regulation, post-transcriptional gene silencing, translational gene silencing, apoptosis, meiosis, and antiviral defense. The utilization of small RNAs represents a specific, energy conserving, and fast mechanism of gene regulation via a core system known as RNA interference.
    Functional & Integrative Genomics 09/2011; 11(3):389-405. · 3.83 Impact Factor