A Deathly DNase Activity for Dicer

Sloan-Kettering Institute, Department of Developmental Biology, 1275 York Ave, Box 252, New York, NY 10065, USA.
Developmental Cell (Impact Factor: 10.37). 05/2010; 18(5):692-4. DOI: 10.1016/j.devcel.2010.05.004
Source: PubMed

ABSTRACT Recently reporting in Science, Nakagawa et al. describe an unexpected role for Dicer in chromosome fragmentation during apoptosis in C. elegans. They find that cleavage of DCR-1 by the caspase CED-3 redirects its regulatory activity, by destroying its dsRNase activity while activating an intrinsic DNase activity.

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