Patterning microfluidic device wettability using flow confinement

School of Engineering and Applied Sciences/Department of Physics, Harvard University, Cambridge, Massachusetts, USA.
Lab on a Chip (Impact Factor: 6.12). 07/2010; 10(14):1774-6. DOI: 10.1039/c004124f
Source: PubMed


We present a simple method to spatially pattern the surface properties of microfluidic devices using flow confinement. Our technique allows surface patterning with micron-scale resolution. To demonstrate its effectiveness, we use it to pattern wettability to form W/O/W and O/W/O double emulsions.

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    • "Interestingly, the idea of using droplets as microreactors has already been brought up in the middle of the 20th century [5]. The real breakthrough came with the recent advances in the droplet-based microfluidic technology [6] [7] [8] [9] [10] [11]. Droplet-based microfluidics emerged at the very beginning of the 21st century as a subdomain of microfluidics [6]. "
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    ABSTRACT: Droplet-based microfluidics appears as a key emerging technology for the miniaturization and automation of biochemical assays. In terms of technology, it stands on two basic pillars: microfluidic devices on the one hand and emulsions on the other hand. Huge progress has been made on large scale integration of devices and batch production of devices. The limiting factor for a full application of the technology is actually not device development, but rather the robust control of emulsion formulations to be used in these devices. We here review the basic problems related to emulsions relevant for microfluidic applications and open up on new promising applications for these systems.
    Current Opinion in Colloid & Interface Science 08/2015; 20(3):183-191. DOI:10.1016/j.cocis.2015.07.005 · 5.84 Impact Factor
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    • "A hydrophobic channel was prepared using a silane-coupling agent. Abate et al. (2010) proposed both hydrophobic and hydrophilic modifications of monolithic microchannels fabricated in PDMS using polyacrilic acid and photoreactive sol–gel mixture containing fluorosilane. Bauer et al. (2010) used sequential layer-bylayer deposition of polyelectrolytes yielding hydrophilic microchannels in PDMS-based microfluidic devices. "
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    Microfluidics and Nanofluidics 06/2014; 14(5). DOI:10.1007/s10404-012-1090-8 · 2.53 Impact Factor
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    • "Microfluidic chips were fabricated by conventional soft lithography techniques [13]. To change the wettability of PDMS chips for double emulsion formation, the chips were coated following a two-step solegel coating procedure [22] "
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    Biomaterials 03/2013; 34(19). DOI:10.1016/j.biomaterials.2013.03.002 · 8.56 Impact Factor
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