Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes.
Shanghai Hengrui Pharmaceuticals Co., Ltd, Shanghai, China.Bioorganic & medicinal chemistry letters (impact factor: 2.65). 06/2010; 20(12):3521-5. DOI:10.1016/j.bmcl.2010.04.138 pp.3521-5
ABSTRACT A series of novel bicyclo[3.3.0]octane derivatives have been synthesized and found to be dipeptidyl peptidase 4 (DPP-4) inhibitors. Compounds 10a and 10b demonstrate good efficacies in oral glucose tolerance tests.
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