A family history study of intermittent explosive disorder

Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA. .
Journal of Psychiatric Research (Impact Factor: 3.96). 11/2010; 44(15):1101-5. DOI: 10.1016/j.jpsychires.2010.04.006
Source: PubMed


Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial.
Blinded and controlled family history study of IED and co-morbid conditions in an outpatient clinical research center for impulsive aggression. The subjects were first-degree relatives of individuals who did and did not meet criteria for IED by DSM-IV and Research Criteria.
Elevated Morbid Risk of IED was observed in relatives of IED Probands compared with relatives of Non-IED Probands. This familial signal of IED was not affected by comorbidity in the IED Probands of comorbidity in the relatives of the IED Probands.
IED, as defined by research criteria, appears to be familial and may not be an artifact of other co-morbid conditions.

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    • "and substance use (35.1–48%) disorders (Kessler et al., 2006; Grant, 2008). A recent family history study found that first-degree relatives of individuals with IED are more likely to have a psychiatric condition compared to control subjects, however specific rates of psychiatric conditions were not reported (Coccaro, 2010). "
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    ABSTRACT: A disorder of impulsive aggression has been included in DSM since the first edition. In DSM-III, this disorder was codified as intermittent explosive disorder, and it was thought to be rare. However, the diagnostic criteria for the disorder were poorly operationalized, and empirical research was limited until research criteria were developed a decade ago. Subsequently, renewed interest in disorders of impulsive aggression led to a recent series of community-based studies that have documented intermittent explosive disorder to be as common as many other psychiatric disorders. Other recent research indicates that compared with DSM-IV criteria for intermittent explosive disorder, research criteria for the disorder better identify individuals with elevated levels of aggression, impulsivity, familial risk of aggression, and abnormalities in neurobiological markers of aggression. In addition, other data strongly suggest important delimitation from other disorders previously thought to obscure the diagnostic uniqueness of intermittent explosive disorder. Overall, these data suggest that the diagnostic validity for the integrated research criteria is substantial and is now sufficient for recognition and inclusion in DSM-5.
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