Article

Effects of morroniside isolated from Corni Fructus on renal lipids and inflammation in type 2 diabetic mice.

Institute of Natural Medicine, University of Toyama, Toyama, Japan.
The Journal of pharmacy and pharmacology 03/2010; 62(3):374-80. DOI:10.1211/jpp.62.03.0013 pp.374-80
Source: PubMed

ABSTRACT The effects of morroniside isolated from Corni Fructus on renal lipids and inflammation provoked by hyperglycaemia were investigated using type 2 diabetic mice.
Morroniside was administered orally to db/db mice at 20 or 100 mg/kg daily for 8 weeks, and its effects were compared with those in vehicle-treated db/db and m/m (non-diabetic) mice. Serum and renal biochemical factors and protein expression related to lipid homeostasis and inflammation were measured.
Morroniside produced significant dose-dependent reductions in serum triglyceride and renal glucose and lipid levels. Morroniside altered the abnormal protein expression of sterol regulatory element binding proteins (SREBP-1 and SREBP-2). In addition, the formation of reactive oxygen species and lipid peroxidation were inhibited in the morroniside-treated db/db mouse group, and the ratio of reduced glutathione to the oxidised form was significantly elevated. These results suggest that morroniside alleviated oxidative stress in the kidneys of db/db mice. Furthermore, 100 mg/kg morroniside down-regulated the expression of nuclear factor-kappaBp65, cyclooxygenase-2 and inducible nitric oxide synthase augmented in db/db mice.
Morroniside may inhibit abnormal lipid metabolism and inflammation due to reactive oxygen species in the kidneys in type 2 diabetes.

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    Article: Anti-inflammatory iridoids of botanical origin.
    A Viljoen, N Mncwangi, I Vermaak
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Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

abnormal lipid metabolism
 
abnormal protein expression
 
Corni Fructus
 
db/db mice
 
inducible nitric oxide synthase augmented
 
lipid homeostasis
 
lipid levels
 
lipid peroxidation
 
morroniside alleviated oxidative stress
 
morroniside-treated db/db mouse group
 
nuclear factor-kappaBp65
 
protein expression
 
reactive oxygen species
 
renal biochemical factors
 
renal glucose
 
renal lipids
 
significant dose-dependent reductions
 
type 2 diabetes
 
type 2 diabetic mice
 
vehicle-treated db/db
 

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