Article

Ethynyldiisopropylsilyl: a new alkynylsilane protecting group and "click" linker.

School of Chemistry, University of Nottingham, Nottingham, NG7 2RD.
Organic Letters (impact factor: 5.86). 06/2010; 12(12):2860-3. DOI:10.1021/ol100968t pp.2860-3
Source: PubMed

ABSTRACT A new silyl-based reagent has been developed for "catch and release" immobilization, combining click chemistry with silyl protection. The traditional "all carbon" attachment to solid supports in a silyl type linker was substituted with a stable triazole, easily assembled using the CuAAC reaction. The methodology introduces a novel ethynyldiiospropylchlorosilane reagent (EDIPS-Cl) as a functionalized protecting group linker.

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Keywords

click chemistry
 
CuAAC reaction
 
methodology introduces
 
novel ethynyldiiospropylchlorosilane reagent
 
silyl type linker
 
solid
 
stable triazole
 

Pallavi Sharma