Ethynyldiisopropylsilyl: A New Alkynylsilane Protecting Group and “Click” Linker

School of Chemistry, University of Nottingham, Nottingham, NG7 2RD.
Organic Letters (Impact Factor: 6.36). 06/2010; 12(12):2860-3. DOI: 10.1021/ol100968t
Source: PubMed


A new silyl-based reagent has been developed for "catch and release" immobilization, combining click chemistry with silyl protection. The traditional "all carbon" attachment to solid supports in a silyl type linker was substituted with a stable triazole, easily assembled using the CuAAC reaction. The methodology introduces a novel ethynyldiiospropylchlorosilane reagent (EDIPS-Cl) as a functionalized protecting group linker.

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